Light-controlled growth factors release on tetrapodal ZnO-Incorporated 3D-printed hydrogels for developing smart wound scaffold

Yogendra Kumar Mishra, Leonard Siebert*, Eder Luna-Cerón, Luis Enrique García-Rivera, Junsung Oh, Jun Hwee Jang, Diego A. Rosas-Gómez, Mitzi D. Pérez-Gómez, Gregor Maschkowitz, Helmut Fickenscher, Daniela Oceguera-Cuevas, Carmen G. Holguín-León, Batzaya Byambaa, Mohammad A. Hussain, Eduardo Enciso-Martínez, Minsung Cho, Yuhan Lee, Nebras Sobahi, Anwarul Hasan, Dennis P. OrgillRainer Adelung, Eunjung Lee, Su Ryon Shin

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.

Original languageEnglish
Article number2007555
JournalAdvanced Functional Materials
Issue number22
Number of pages20
Publication statusPublished - 26. May 2021

Bibliographical note

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© 2021 Wiley-VCH GmbH


  • 3D printing
  • controlled release
  • hydrogel composites
  • photoactive
  • wound healing
  • zinc oxide tetrapod


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