Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT

Simon Husby; Gustav Jørgensen; Francesco Favero; Jakob Schmidt Jespersen; Francisco G. Rodriguez-Gonzalez; Christian Nielsen; Betina Sorensen; Lene H. Ebbesen; John Bæch; Eva K. Haastrup; Pär Josefsson; Michael Thorsgaard; Peter Brown; Tarec C. El-Galaly; Thomas Stauffer Larsen; Joachim Weischenfeldt; Kirsten Grønbæk

doi:10.1038/s41409-022-01580-2

Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT

Simon Husby^*, Gustav Jørgensen, Francesco Favero, Jakob Schmidt Jespersen, Francisco G. Rodriguez-Gonzalez, Christian Nielsen, Betina Sorensen, Lene H. Ebbesen, John Bæch, Eva K. Haastrup, Pär Josefsson, Michael Thorsgaard, Peter Brown, Tarec C. El-Galaly, Thomas Stauffer Larsen, Joachim Weischenfeldt, Kirsten Grønbæk

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

Original language	English
Journal	Bone Marrow Transplantation
Volume	57
Issue number	4
Pages (from-to)	674-677
ISSN	0268-3369
DOIs	https://doi.org/10.1038/s41409-022-01580-2
Publication status	Published - Apr 2022

Keywords

Clonal Hematopoiesis
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma
T-Lymphocytes
Transplantation, Autologous

Documents & Links

10.1038/s41409-022-01580-2

Cite this

Husby, S., Jørgensen, G., Favero, F., Jespersen, J. S., Rodriguez-Gonzalez, F. G., Nielsen, C., Sorensen, B., Ebbesen, L. H., Bæch, J., Haastrup, E. K., Josefsson, P., Thorsgaard, M., Brown, P., El-Galaly, T. C., Larsen, T. S., Weischenfeldt, J., & Grønbæk, K. (2022). Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT. Bone Marrow Transplantation, 57(4), 674-677. https://doi.org/10.1038/s41409-022-01580-2

@article{2ced833cddf34c17a0ab56e56ce17df0,

title = "Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT",

keywords = "Clonal Hematopoiesis, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, T-Lymphocytes, Transplantation, Autologous",

author = "Simon Husby and Gustav J{\o}rgensen and Francesco Favero and Jespersen, {Jakob Schmidt} and Rodriguez-Gonzalez, {Francisco G.} and Christian Nielsen and Betina Sorensen and Ebbesen, {Lene H.} and John B{\ae}ch and Haastrup, {Eva K.} and P{\"a}r Josefsson and Michael Thorsgaard and Peter Brown and El-Galaly, {Tarec C.} and Larsen, {Thomas Stauffer} and Joachim Weischenfeldt and Kirsten Gr{\o}nb{\ae}k",

note = "Funding Information: The authors wish to thank all participating centres and technical staff. SH and G{\O}J are funded by scholarships from Rigshospitalet{\textquoteright}s Research Fund. Reagents were supported by supported by a grant from Region Hovedstadens{\textquoteright} Research Foundation. This study was furthermore supported by grants from The Denmark-America Fund, Dagmar Marshalls Fund, The Danish Cancer Society, Reinholdt W. Jorks Fund, A.P. M{\o}ller Fund (L{\ae}gefonden), Sejer Persson & Lis Kl{\"u}wer Persson{\textquoteright}s Fund. SH and KG are also funded by the Novo Nordisk Foundation (Novo Nordisk Foundation Center for Stem Cell Biology, DanStem; grant NNF17CC0027852). The project is part of the Danish Research Center for Precision Medicine in Blood Cancers funded by the Danish Cancer Society grant no. R223-A13071. ",

year = "2022",

month = apr,

doi = "10.1038/s41409-022-01580-2",

language = "English",

volume = "57",

pages = "674--677",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "4",

}

Husby, S, Jørgensen, G, Favero, F, Jespersen, JS, Rodriguez-Gonzalez, FG, Nielsen, C, Sorensen, B, Ebbesen, LH, Bæch, J, Haastrup, EK, Josefsson, P, Thorsgaard, M, Brown, P, El-Galaly, TC , Larsen, TS, Weischenfeldt, J & Grønbæk, K 2022, 'Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT', Bone Marrow Transplantation, vol. 57, no. 4, pp. 674-677. https://doi.org/10.1038/s41409-022-01580-2

TY - JOUR

T1 - Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT

AU - Husby, Simon

AU - Jørgensen, Gustav

AU - Favero, Francesco

AU - Jespersen, Jakob Schmidt

AU - Rodriguez-Gonzalez, Francisco G.

AU - Nielsen, Christian

AU - Sorensen, Betina

AU - Ebbesen, Lene H.

AU - Bæch, John

AU - Haastrup, Eva K.

AU - Josefsson, Pär

AU - Thorsgaard, Michael

AU - Brown, Peter

AU - El-Galaly, Tarec C.

AU - Larsen, Thomas Stauffer

AU - Weischenfeldt, Joachim

AU - Grønbæk, Kirsten

N1 - Funding Information: The authors wish to thank all participating centres and technical staff. SH and GØJ are funded by scholarships from Rigshospitalet’s Research Fund. Reagents were supported by supported by a grant from Region Hovedstadens’ Research Foundation. This study was furthermore supported by grants from The Denmark-America Fund, Dagmar Marshalls Fund, The Danish Cancer Society, Reinholdt W. Jorks Fund, A.P. Møller Fund (Lægefonden), Sejer Persson & Lis Klüwer Persson’s Fund. SH and KG are also funded by the Novo Nordisk Foundation (Novo Nordisk Foundation Center for Stem Cell Biology, DanStem; grant NNF17CC0027852). The project is part of the Danish Research Center for Precision Medicine in Blood Cancers funded by the Danish Cancer Society grant no. R223-A13071.

PY - 2022/4

Y1 - 2022/4

KW - Clonal Hematopoiesis

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Lymphoma

KW - T-Lymphocytes

KW - Transplantation, Autologous

U2 - 10.1038/s41409-022-01580-2

DO - 10.1038/s41409-022-01580-2

M3 - Comment/debate

C2 - 35124694

AN - SCOPUS:85124283381

SN - 0268-3369

VL - 57

SP - 674

EP - 677

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 4

ER -