Letter to Editor: Response to AASLD Editorial/Message from the President

Ronald L. Koretz; Janus C. Jakobsen; Goran Hauser; Dimitrinka Nikolova; Christian Gluud

doi:10.1002/hep.30298

Letter to Editor: Response to AASLD Editorial/Message from the President

Ronald L. Koretz, Janus C. Jakobsen, Goran Hauser, Dimitrinka Nikolova, Christian Gluud

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Hepatology
Volume	69
Issue number	5
Pages (from-to)	2300
Number of pages	1
ISSN	0270-9139
DOIs	https://doi.org/10.1002/hep.30298
Publication status	Published - May 2019

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10.1002/hep.30298

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title = "Letter to Editor: Response to AASLD Editorial/Message from the President",

abstract = "A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.",

author = "Koretz, {Ronald L.} and Jakobsen, {Janus C.} and Goran Hauser and Dimitrinka Nikolova and Christian Gluud",

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T2 - Response to AASLD Editorial/Message from the President

AU - Koretz, Ronald L.

AU - Jakobsen, Janus C.

AU - Hauser, Goran

AU - Nikolova, Dimitrinka

AU - Gluud, Christian

PY - 2019/5

Y1 - 2019/5

N2 - A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.

AB - A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.

U2 - 10.1002/hep.30298

DO - 10.1002/hep.30298

M3 - Comment/debate

C2 - 30276829

AN - SCOPUS:85064233197

SN - 0270-9139

VL - 69

SP - 2300

JO - Hepatology

JF - Hepatology

IS - 5

ER -

Letter to Editor: Response to AASLD Editorial/Message from the President

Abstract

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