Letter to Editor: Response to AASLD Editorial/Message from the President

Ronald L. Koretz, Janus C. Jakobsen, Goran Hauser, Dimitrinka Nikolova, Christian Gluud

Research output: Contribution to journalComment/debateResearchpeer-review


A commentary [1] criticized our systematic review regarding the use of direct-acting agents (DAAs) in chronic hepatitis C [2]. The following represents our major disagreements. Sustained virological response (SVR) is a non-validated surrogate outcome. The principles of evidence-based medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel benefits in clinical outcomes [3]. This article is protected by copyright. All rights reserved.

Original languageEnglish
Issue number5
Pages (from-to)2300
Number of pages1
Publication statusPublished - May 2019


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