Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial

Lisette Okkels Jensen, Michael Maeng, Per Thayssen, Anton Villadsen, Lars Romer Krusell, Hans Erik Botker, Knud Erik Pedersen, Jens Aaroe, Evald Hoej Christiansen, Thomas Vesterlund, Knud Noerregaard Hansen, Jan Ravkilde, Hans-Henrik Tilsted Hansen, Jens Flensted Lassen, Leif Thuesen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to neointimal hyperplasia (NIH). The aim of this study was to use quantitative coronary angiography (QCA) and volumetric intravascular ultrasound (IVUS) to evaluate the effects of the sirolimus-eluting Cypher® stent (SES) and the zotarolimus-eluting Endeavor® stent (ZES) on angiographic late lumen loss and intima hyperplasia in diabetic patients.
Original languageEnglish
JournalEuroIntervention
Volume7
Issue number3
Pages (from-to)323-31
Number of pages9
ISSN1774-024X
DOIs
Publication statusPublished - 2011

Fingerprint

Hyperplasia
Stents
Coronary Restenosis
Coronary Angiography
Diabetes Mellitus
zotarolimus

Keywords

  • Aged
  • Angioplasty, Balloon, Laser-Assisted
  • Coronary Angiography
  • Coronary Artery Disease
  • Coronary Restenosis
  • Diabetes Complications
  • Drug-Eluting Stents
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperplasia
  • Male
  • Middle Aged
  • Neointima
  • Risk Factors
  • Single-Blind Method
  • Sirolimus
  • Treatment Outcome
  • Ultrasonography, Interventional

Cite this

Jensen, Lisette Okkels ; Maeng, Michael ; Thayssen, Per ; Villadsen, Anton ; Krusell, Lars Romer ; Botker, Hans Erik ; Pedersen, Knud Erik ; Aaroe, Jens ; Christiansen, Evald Hoej ; Vesterlund, Thomas ; Hansen, Knud Noerregaard ; Ravkilde, Jan ; Hansen, Hans-Henrik Tilsted ; Lassen, Jens Flensted ; Thuesen, Leif. / Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial. In: EuroIntervention. 2011 ; Vol. 7, No. 3. pp. 323-31.
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Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial. / Jensen, Lisette Okkels; Maeng, Michael; Thayssen, Per; Villadsen, Anton; Krusell, Lars Romer; Botker, Hans Erik; Pedersen, Knud Erik; Aaroe, Jens; Christiansen, Evald Hoej; Vesterlund, Thomas; Hansen, Knud Noerregaard; Ravkilde, Jan; Hansen, Hans-Henrik Tilsted; Lassen, Jens Flensted; Thuesen, Leif.

In: EuroIntervention, Vol. 7, No. 3, 2011, p. 323-31.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial

AU - Jensen, Lisette Okkels

AU - Maeng, Michael

AU - Thayssen, Per

AU - Villadsen, Anton

AU - Krusell, Lars Romer

AU - Botker, Hans Erik

AU - Pedersen, Knud Erik

AU - Aaroe, Jens

AU - Christiansen, Evald Hoej

AU - Vesterlund, Thomas

AU - Hansen, Knud Noerregaard

AU - Ravkilde, Jan

AU - Hansen, Hans-Henrik Tilsted

AU - Lassen, Jens Flensted

AU - Thuesen, Leif

PY - 2011

Y1 - 2011

N2 - Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to neointimal hyperplasia (NIH). The aim of this study was to use quantitative coronary angiography (QCA) and volumetric intravascular ultrasound (IVUS) to evaluate the effects of the sirolimus-eluting Cypher® stent (SES) and the zotarolimus-eluting Endeavor® stent (ZES) on angiographic late lumen loss and intima hyperplasia in diabetic patients.

AB - Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to neointimal hyperplasia (NIH). The aim of this study was to use quantitative coronary angiography (QCA) and volumetric intravascular ultrasound (IVUS) to evaluate the effects of the sirolimus-eluting Cypher® stent (SES) and the zotarolimus-eluting Endeavor® stent (ZES) on angiographic late lumen loss and intima hyperplasia in diabetic patients.

KW - Aged

KW - Angioplasty, Balloon, Laser-Assisted

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Coronary Restenosis

KW - Diabetes Complications

KW - Drug-Eluting Stents

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hyperplasia

KW - Male

KW - Middle Aged

KW - Neointima

KW - Risk Factors

KW - Single-Blind Method

KW - Sirolimus

KW - Treatment Outcome

KW - Ultrasonography, Interventional

U2 - 10.4244/EIJV7I3A56

DO - 10.4244/EIJV7I3A56

M3 - Journal article

C2 - 21729834

VL - 7

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JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

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