Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A Scott, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, Jian'an Luan, Reedik Mägi, Rona J Strawbridge, Emil Rehnberg, Stefan Gustafsson, Stavroula Kanoni, Laura J Rasmussen-Torvik, Loïc Yengo, Cecile Lecoeur, Dmitry Shungin, Serena Sanna, Carlo Sidore, Paul C D Johnson, J Wouter Jukema, Toby Johnson & 31 others Anubha Mahajan, Niek Verweij, Gudmar Thorleifsson, Jouke-Jan Hottenga, Sonia Shah, Albert V Smith, Bengt Sennblad, Christian Gieger, Perttu Salo, Markus Perola, Nicholas J Timpson, David M Evans, Beate St Pourcain, Ying Wu, Jeanette S Andrews, Jennie Hui, Lawrence F Bielak, Wei Zhao, Momoko Horikoshi, Pau Navarro, Aaron Isaacs, Jeffrey R O'Connell, Kathleen Stirrups, Veronique Vitart, Caroline Hayward, Tõnu Esko, Evelin Mihailov, Ross M Fraser, Tove Fall, Kirsten O Kyvik, DIAGRAM Consortium

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q
Original languageEnglish
JournalNature Genetics
Volume44
Issue number9
Pages (from-to)991-1005
ISSN1061-4036
DOIs
Publication statusPublished - 2012

Fingerprint

Genome-Wide Association Study
Type 2 Diabetes Mellitus
Meta-Analysis

Keywords

  • Adult
  • Animals
  • Blood Glucose
  • Fasting
  • Female
  • Gene Frequency
  • Genome-Wide Association Study
  • Humans
  • Insulin
  • Male
  • Metabolic Networks and Pathways
  • Mice
  • Osmolar Concentration
  • Quantitative Trait Loci

Cite this

Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., ... DIAGRAM Consortium (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44(9), 991-1005. https://doi.org/10.1038/ng.2385
Scott, Robert A ; Lagou, Vasiliki ; Welch, Ryan P ; Wheeler, Eleanor ; Montasser, May E ; Luan, Jian'an ; Mägi, Reedik ; Strawbridge, Rona J ; Rehnberg, Emil ; Gustafsson, Stefan ; Kanoni, Stavroula ; Rasmussen-Torvik, Laura J ; Yengo, Loïc ; Lecoeur, Cecile ; Shungin, Dmitry ; Sanna, Serena ; Sidore, Carlo ; Johnson, Paul C D ; Jukema, J Wouter ; Johnson, Toby ; Mahajan, Anubha ; Verweij, Niek ; Thorleifsson, Gudmar ; Hottenga, Jouke-Jan ; Shah, Sonia ; Smith, Albert V ; Sennblad, Bengt ; Gieger, Christian ; Salo, Perttu ; Perola, Markus ; Timpson, Nicholas J ; Evans, David M ; Pourcain, Beate St ; Wu, Ying ; Andrews, Jeanette S ; Hui, Jennie ; Bielak, Lawrence F ; Zhao, Wei ; Horikoshi, Momoko ; Navarro, Pau ; Isaacs, Aaron ; O'Connell, Jeffrey R ; Stirrups, Kathleen ; Vitart, Veronique ; Hayward, Caroline ; Esko, Tõnu ; Mihailov, Evelin ; Fraser, Ross M ; Fall, Tove ; Kyvik, Kirsten O ; DIAGRAM Consortium. / Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. In: Nature Genetics. 2012 ; Vol. 44, No. 9. pp. 991-1005.
@article{f30593c47fbf4be79ac4e06da8a296b6,
title = "Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways",
abstract = "Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q",
keywords = "Adult, Animals, Blood Glucose, Fasting, Female, Gene Frequency, Genome-Wide Association Study, Humans, Insulin, Male, Metabolic Networks and Pathways, Mice, Osmolar Concentration, Quantitative Trait Loci",
author = "Scott, {Robert A} and Vasiliki Lagou and Welch, {Ryan P} and Eleanor Wheeler and Montasser, {May E} and Jian'an Luan and Reedik M{\"a}gi and Strawbridge, {Rona J} and Emil Rehnberg and Stefan Gustafsson and Stavroula Kanoni and Rasmussen-Torvik, {Laura J} and Lo{\"i}c Yengo and Cecile Lecoeur and Dmitry Shungin and Serena Sanna and Carlo Sidore and Johnson, {Paul C D} and Jukema, {J Wouter} and Toby Johnson and Anubha Mahajan and Niek Verweij and Gudmar Thorleifsson and Jouke-Jan Hottenga and Sonia Shah and Smith, {Albert V} and Bengt Sennblad and Christian Gieger and Perttu Salo and Markus Perola and Timpson, {Nicholas J} and Evans, {David M} and Pourcain, {Beate St} and Ying Wu and Andrews, {Jeanette S} and Jennie Hui and Bielak, {Lawrence F} and Wei Zhao and Momoko Horikoshi and Pau Navarro and Aaron Isaacs and O'Connell, {Jeffrey R} and Kathleen Stirrups and Veronique Vitart and Caroline Hayward and T{\~o}nu Esko and Evelin Mihailov and Fraser, {Ross M} and Tove Fall and Kyvik, {Kirsten O} and {DIAGRAM Consortium}",
year = "2012",
doi = "10.1038/ng.2385",
language = "English",
volume = "44",
pages = "991--1005",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",

}

Scott, RA, Lagou, V, Welch, RP, Wheeler, E, Montasser, ME, Luan, J, Mägi, R, Strawbridge, RJ, Rehnberg, E, Gustafsson, S, Kanoni, S, Rasmussen-Torvik, LJ, Yengo, L, Lecoeur, C, Shungin, D, Sanna, S, Sidore, C, Johnson, PCD, Jukema, JW, Johnson, T, Mahajan, A, Verweij, N, Thorleifsson, G, Hottenga, J-J, Shah, S, Smith, AV, Sennblad, B, Gieger, C, Salo, P, Perola, M, Timpson, NJ, Evans, DM, Pourcain, BS, Wu, Y, Andrews, JS, Hui, J, Bielak, LF, Zhao, W, Horikoshi, M, Navarro, P, Isaacs, A, O'Connell, JR, Stirrups, K, Vitart, V, Hayward, C, Esko, T, Mihailov, E, Fraser, RM, Fall, T, Kyvik, KO & DIAGRAM Consortium 2012, 'Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways', Nature Genetics, vol. 44, no. 9, pp. 991-1005. https://doi.org/10.1038/ng.2385

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. / Scott, Robert A; Lagou, Vasiliki; Welch, Ryan P; Wheeler, Eleanor; Montasser, May E; Luan, Jian'an; Mägi, Reedik; Strawbridge, Rona J; Rehnberg, Emil; Gustafsson, Stefan; Kanoni, Stavroula; Rasmussen-Torvik, Laura J; Yengo, Loïc; Lecoeur, Cecile; Shungin, Dmitry; Sanna, Serena; Sidore, Carlo; Johnson, Paul C D; Jukema, J Wouter; Johnson, Toby; Mahajan, Anubha; Verweij, Niek; Thorleifsson, Gudmar; Hottenga, Jouke-Jan; Shah, Sonia; Smith, Albert V; Sennblad, Bengt; Gieger, Christian; Salo, Perttu; Perola, Markus; Timpson, Nicholas J; Evans, David M; Pourcain, Beate St; Wu, Ying; Andrews, Jeanette S; Hui, Jennie; Bielak, Lawrence F; Zhao, Wei; Horikoshi, Momoko; Navarro, Pau; Isaacs, Aaron; O'Connell, Jeffrey R; Stirrups, Kathleen; Vitart, Veronique; Hayward, Caroline; Esko, Tõnu; Mihailov, Evelin; Fraser, Ross M; Fall, Tove; Kyvik, Kirsten O; DIAGRAM Consortium.

In: Nature Genetics, Vol. 44, No. 9, 2012, p. 991-1005.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

AU - Scott, Robert A

AU - Lagou, Vasiliki

AU - Welch, Ryan P

AU - Wheeler, Eleanor

AU - Montasser, May E

AU - Luan, Jian'an

AU - Mägi, Reedik

AU - Strawbridge, Rona J

AU - Rehnberg, Emil

AU - Gustafsson, Stefan

AU - Kanoni, Stavroula

AU - Rasmussen-Torvik, Laura J

AU - Yengo, Loïc

AU - Lecoeur, Cecile

AU - Shungin, Dmitry

AU - Sanna, Serena

AU - Sidore, Carlo

AU - Johnson, Paul C D

AU - Jukema, J Wouter

AU - Johnson, Toby

AU - Mahajan, Anubha

AU - Verweij, Niek

AU - Thorleifsson, Gudmar

AU - Hottenga, Jouke-Jan

AU - Shah, Sonia

AU - Smith, Albert V

AU - Sennblad, Bengt

AU - Gieger, Christian

AU - Salo, Perttu

AU - Perola, Markus

AU - Timpson, Nicholas J

AU - Evans, David M

AU - Pourcain, Beate St

AU - Wu, Ying

AU - Andrews, Jeanette S

AU - Hui, Jennie

AU - Bielak, Lawrence F

AU - Zhao, Wei

AU - Horikoshi, Momoko

AU - Navarro, Pau

AU - Isaacs, Aaron

AU - O'Connell, Jeffrey R

AU - Stirrups, Kathleen

AU - Vitart, Veronique

AU - Hayward, Caroline

AU - Esko, Tõnu

AU - Mihailov, Evelin

AU - Fraser, Ross M

AU - Fall, Tove

AU - Kyvik, Kirsten O

AU - DIAGRAM Consortium

PY - 2012

Y1 - 2012

N2 - Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q

AB - Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q

KW - Adult

KW - Animals

KW - Blood Glucose

KW - Fasting

KW - Female

KW - Gene Frequency

KW - Genome-Wide Association Study

KW - Humans

KW - Insulin

KW - Male

KW - Metabolic Networks and Pathways

KW - Mice

KW - Osmolar Concentration

KW - Quantitative Trait Loci

U2 - 10.1038/ng.2385

DO - 10.1038/ng.2385

M3 - Journal article

VL - 44

SP - 991

EP - 1005

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -