Large porcine model of profound acute ischemic cardiogenic shock

Ole K. Møller-Helgestad*, Hanne B. Ravn, Jacob E. Møller

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

Original languageEnglish
Title of host publicationExperimental Models of Cardiovascular Diseases
EditorsKiyotake Ishikawa
PublisherHumana Press
Publication date2018
Pages343-352
Chapter27
ISBN (Print)9781493985968
ISBN (Electronic)9781493985975
DOIs
Publication statusPublished - 2018
SeriesMethods in Molecular Biology
Volume1816
ISSN1064-3745

Fingerprint

Cardiogenic Shock
Microspheres
Cause of Death

Keywords

  • Acute heart failure
  • Cardiogenic shock
  • Coronary ischemia
  • End-organ perfusion
  • Hemodynamics
  • Microspheres
  • Pathophysiology
  • Heart Failure/pathology
  • Swine/physiology
  • Shock, Cardiogenic/pathology
  • Animals
  • Heart Ventricles/pathology
  • Disease Models, Animal

Cite this

Møller-Helgestad, O. K., Ravn, H. B., & Møller, J. E. (2018). Large porcine model of profound acute ischemic cardiogenic shock. In K. Ishikawa (Ed.), Experimental Models of Cardiovascular Diseases (pp. 343-352). Humana Press. Methods in Molecular Biology, Vol.. 1816 https://doi.org/10.1007/978-1-4939-8597-5_27
Møller-Helgestad, Ole K. ; Ravn, Hanne B. ; Møller, Jacob E. / Large porcine model of profound acute ischemic cardiogenic shock. Experimental Models of Cardiovascular Diseases. editor / Kiyotake Ishikawa. Humana Press, 2018. pp. 343-352 (Methods in Molecular Biology, Vol. 1816).
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Møller-Helgestad, OK, Ravn, HB & Møller, JE 2018, Large porcine model of profound acute ischemic cardiogenic shock. in K Ishikawa (ed.), Experimental Models of Cardiovascular Diseases. Humana Press, Methods in Molecular Biology, vol. 1816, pp. 343-352. https://doi.org/10.1007/978-1-4939-8597-5_27

Large porcine model of profound acute ischemic cardiogenic shock. / Møller-Helgestad, Ole K.; Ravn, Hanne B.; Møller, Jacob E.

Experimental Models of Cardiovascular Diseases. ed. / Kiyotake Ishikawa. Humana Press, 2018. p. 343-352 (Methods in Molecular Biology, Vol. 1816).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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AU - Møller-Helgestad, Ole K.

AU - Ravn, Hanne B.

AU - Møller, Jacob E.

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N2 - Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

AB - Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

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KW - End-organ perfusion

KW - Hemodynamics

KW - Microspheres

KW - Pathophysiology

KW - Heart Failure/pathology

KW - Swine/physiology

KW - Shock, Cardiogenic/pathology

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KW - Heart Ventricles/pathology

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Møller-Helgestad OK, Ravn HB, Møller JE. Large porcine model of profound acute ischemic cardiogenic shock. In Ishikawa K, editor, Experimental Models of Cardiovascular Diseases. Humana Press. 2018. p. 343-352. (Methods in Molecular Biology, Vol. 1816). https://doi.org/10.1007/978-1-4939-8597-5_27