Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population

Torben Albert Devantier, Bjarne L Nørgaard, Niels Peter Sand, Rikke Elmose Mols, Leslie Foldager, Axel Cosmus Pyndt Diederichsen, Kristian Korsgaard Thomsen, Jesper Møller Jensen, Poul Videbech

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Abstract

BACKGROUND: Depression is associated with coronary artery disease, and atherosclerosis seems to play a central role in this relation. In several studies, multislice computed tomography (CT) has been applied for detection and quantification of coronary artery calcification (CAC) in relation to depression. To our knowledge, only one previous study has investigated the relation between CAC and depression in an unselected population. METHODS: A total of 617 persons were randomly selected from the background population. The participants underwent CT of the heart and were screened for depression by use of the Major Depression Inventory questionnaire. Quantification of CAC was performed using the Agatston method. The Mann-Whitney U test, Spearman's correlational analysis, and logistic regression were used to assess the association between depression and CAC. RESULTS: The median Agatston score was not significantly different in subjects with depression than in those without depression (p = 0.783), and depression scores did not correlate significantly with Agatston scores (r = 0.023; 95% CI: -0.056-0.102; p = 0.573). This was also the case when correlational analyses were stratified by sex or age. Furthermore, after the exclusion of an outlier, no significant association between CAC and depression was found in either the unadjusted or adjusted logistic regression model, OR = 1.00 (95% CI: 0.88-1.14; p = 0.994) and OR = 1.04 (95% CI: 0.92-1.18; p = 0.529), respectively. CONCLUSIONS: Depression was not associated with CAC in an unselected middle-aged population, although a trend-level association was found in men (p = 0.086).
Original languageEnglish
JournalPsychosomatics
Volume54
Issue number5
Pages (from-to)458-65
Number of pages8
ISSN0033-3182
DOIs
Publication statusPublished - 2013

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Population
Logistic Models
Coronary Artery Disease
Multidetector Computed Tomography
Nonparametric Statistics
Equipment and Supplies
Computed Tomography
Quantification
Logistic Regression
Surveys and Questionnaires

Cite this

Devantier, Torben Albert ; Nørgaard, Bjarne L ; Sand, Niels Peter ; Mols, Rikke Elmose ; Foldager, Leslie ; Diederichsen, Axel Cosmus Pyndt ; Korsgaard Thomsen, Kristian ; Jensen, Jesper Møller ; Videbech, Poul. / Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population. In: Psychosomatics. 2013 ; Vol. 54, No. 5. pp. 458-65.
@article{8df41ddd80d940ab9a4d9a5f1bcda7b2,
title = "Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population",
abstract = "BACKGROUND: Depression is associated with coronary artery disease, and atherosclerosis seems to play a central role in this relation. In several studies, multislice computed tomography (CT) has been applied for detection and quantification of coronary artery calcification (CAC) in relation to depression. To our knowledge, only one previous study has investigated the relation between CAC and depression in an unselected population. METHODS: A total of 617 persons were randomly selected from the background population. The participants underwent CT of the heart and were screened for depression by use of the Major Depression Inventory questionnaire. Quantification of CAC was performed using the Agatston method. The Mann-Whitney U test, Spearman's correlational analysis, and logistic regression were used to assess the association between depression and CAC. RESULTS: The median Agatston score was not significantly different in subjects with depression than in those without depression (p = 0.783), and depression scores did not correlate significantly with Agatston scores (r = 0.023; 95{\%} CI: -0.056-0.102; p = 0.573). This was also the case when correlational analyses were stratified by sex or age. Furthermore, after the exclusion of an outlier, no significant association between CAC and depression was found in either the unadjusted or adjusted logistic regression model, OR = 1.00 (95{\%} CI: 0.88-1.14; p = 0.994) and OR = 1.04 (95{\%} CI: 0.92-1.18; p = 0.529), respectively. CONCLUSIONS: Depression was not associated with CAC in an unselected middle-aged population, although a trend-level association was found in men (p = 0.086).",
author = "Devantier, {Torben Albert} and N{\o}rgaard, {Bjarne L} and Sand, {Niels Peter} and Mols, {Rikke Elmose} and Leslie Foldager and Diederichsen, {Axel Cosmus Pyndt} and {Korsgaard Thomsen}, Kristian and Jensen, {Jesper M{\o}ller} and Poul Videbech",
note = "Copyright {\circledC} 2013 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.",
year = "2013",
doi = "10.1016/j.psym.2013.01.005",
language = "English",
volume = "54",
pages = "458--65",
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Devantier, TA, Nørgaard, BL, Sand, NP, Mols, RE, Foldager, L, Diederichsen, ACP, Korsgaard Thomsen, K, Jensen, JM & Videbech, P 2013, 'Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population', Psychosomatics, vol. 54, no. 5, pp. 458-65. https://doi.org/10.1016/j.psym.2013.01.005

Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population. / Devantier, Torben Albert; Nørgaard, Bjarne L; Sand, Niels Peter; Mols, Rikke Elmose; Foldager, Leslie; Diederichsen, Axel Cosmus Pyndt; Korsgaard Thomsen, Kristian; Jensen, Jesper Møller; Videbech, Poul.

In: Psychosomatics, Vol. 54, No. 5, 2013, p. 458-65.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Lack of Correlation Between Depression and Coronary Artery Calcification in a Non-Selected Danish Population

AU - Devantier, Torben Albert

AU - Nørgaard, Bjarne L

AU - Sand, Niels Peter

AU - Mols, Rikke Elmose

AU - Foldager, Leslie

AU - Diederichsen, Axel Cosmus Pyndt

AU - Korsgaard Thomsen, Kristian

AU - Jensen, Jesper Møller

AU - Videbech, Poul

N1 - Copyright © 2013 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Depression is associated with coronary artery disease, and atherosclerosis seems to play a central role in this relation. In several studies, multislice computed tomography (CT) has been applied for detection and quantification of coronary artery calcification (CAC) in relation to depression. To our knowledge, only one previous study has investigated the relation between CAC and depression in an unselected population. METHODS: A total of 617 persons were randomly selected from the background population. The participants underwent CT of the heart and were screened for depression by use of the Major Depression Inventory questionnaire. Quantification of CAC was performed using the Agatston method. The Mann-Whitney U test, Spearman's correlational analysis, and logistic regression were used to assess the association between depression and CAC. RESULTS: The median Agatston score was not significantly different in subjects with depression than in those without depression (p = 0.783), and depression scores did not correlate significantly with Agatston scores (r = 0.023; 95% CI: -0.056-0.102; p = 0.573). This was also the case when correlational analyses were stratified by sex or age. Furthermore, after the exclusion of an outlier, no significant association between CAC and depression was found in either the unadjusted or adjusted logistic regression model, OR = 1.00 (95% CI: 0.88-1.14; p = 0.994) and OR = 1.04 (95% CI: 0.92-1.18; p = 0.529), respectively. CONCLUSIONS: Depression was not associated with CAC in an unselected middle-aged population, although a trend-level association was found in men (p = 0.086).

AB - BACKGROUND: Depression is associated with coronary artery disease, and atherosclerosis seems to play a central role in this relation. In several studies, multislice computed tomography (CT) has been applied for detection and quantification of coronary artery calcification (CAC) in relation to depression. To our knowledge, only one previous study has investigated the relation between CAC and depression in an unselected population. METHODS: A total of 617 persons were randomly selected from the background population. The participants underwent CT of the heart and were screened for depression by use of the Major Depression Inventory questionnaire. Quantification of CAC was performed using the Agatston method. The Mann-Whitney U test, Spearman's correlational analysis, and logistic regression were used to assess the association between depression and CAC. RESULTS: The median Agatston score was not significantly different in subjects with depression than in those without depression (p = 0.783), and depression scores did not correlate significantly with Agatston scores (r = 0.023; 95% CI: -0.056-0.102; p = 0.573). This was also the case when correlational analyses were stratified by sex or age. Furthermore, after the exclusion of an outlier, no significant association between CAC and depression was found in either the unadjusted or adjusted logistic regression model, OR = 1.00 (95% CI: 0.88-1.14; p = 0.994) and OR = 1.04 (95% CI: 0.92-1.18; p = 0.529), respectively. CONCLUSIONS: Depression was not associated with CAC in an unselected middle-aged population, although a trend-level association was found in men (p = 0.086).

U2 - 10.1016/j.psym.2013.01.005

DO - 10.1016/j.psym.2013.01.005

M3 - Journal article

C2 - 23414849

VL - 54

SP - 458

EP - 465

JO - Psychosomatics

JF - Psychosomatics

SN - 0033-3182

IS - 5

ER -