Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain

Stine T Zwisler, Thomas P Enggaard, Soeren Mikkelsen, Céline Verstuyft, Laurent Becquemont, Soeren H Sindrup, Kim Brøsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. Methods: There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve(0-24 hours). A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a non-responder. Results: For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4% vs 118AG/118GG = 17.0%, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5% vs 3435CT/3435TT = 15.8%, P = .85; 2677GG = 17.8% vs 2677GT/2677TT = 15.8%, P = .74) or pain ratings. Conclusion: No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.
Original languageEnglish
JournalThe Journal of Clinical Pharmacology
Volume52
Issue number2
Pages (from-to)234–242
ISSN0091-2700
DOIs
Publication statusPublished - 2012

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Oxycodone
Single Nucleotide Polymorphism
Alleles
Area Under Curve

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@article{f41dc312ef28415f8a75a9f3b857b730,
title = "Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain",
abstract = "Purpose: The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. Methods: There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve(0-24 hours). A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a non-responder. Results: For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4{\%} vs 118AG/118GG = 17.0{\%}, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5{\%} vs 3435CT/3435TT = 15.8{\%}, P = .85; 2677GG = 17.8{\%} vs 2677GT/2677TT = 15.8{\%}, P = .74) or pain ratings. Conclusion: No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.",
author = "Zwisler, {Stine T} and Enggaard, {Thomas P} and Soeren Mikkelsen and C{\'e}line Verstuyft and Laurent Becquemont and Sindrup, {Soeren H} and Kim Br{\o}sen",
year = "2012",
doi = "10.1177/0091270010397729",
language = "English",
volume = "52",
pages = "234–242",
journal = "The Journal of Clinical Pharmacology",
issn = "0091-2700",
publisher = "SAGE Publications",
number = "2",

}

Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain. / Zwisler, Stine T; Enggaard, Thomas P; Mikkelsen, Soeren; Verstuyft, Céline; Becquemont, Laurent; Sindrup, Soeren H; Brøsen, Kim.

In: The Journal of Clinical Pharmacology, Vol. 52, No. 2, 2012, p. 234–242.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain

AU - Zwisler, Stine T

AU - Enggaard, Thomas P

AU - Mikkelsen, Soeren

AU - Verstuyft, Céline

AU - Becquemont, Laurent

AU - Sindrup, Soeren H

AU - Brøsen, Kim

PY - 2012

Y1 - 2012

N2 - Purpose: The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. Methods: There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve(0-24 hours). A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a non-responder. Results: For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4% vs 118AG/118GG = 17.0%, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5% vs 3435CT/3435TT = 15.8%, P = .85; 2677GG = 17.8% vs 2677GT/2677TT = 15.8%, P = .74) or pain ratings. Conclusion: No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.

AB - Purpose: The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. Methods: There were 268 patients with postoperative pain after, primarily, thyroidectomy. At given times during the first 24 hours postoperatively, their pain was rated at rest and during activity according to a numeric rating scale (0 = no pain, 10 = worst possible pain) and calculated as pain time area under the curve(0-24 hours). A negative answer in a final questionnaire and/or the use of rescue medication categorized a patient as a non-responder. Results: For OPRM1, there was no difference found between the wild type and the variant allele in the percentages of nonresponders (118AA = 16.4% vs 118AG/118GG = 17.0%, P = 1.0) or in the pain ratings. For ABCB1, no difference was found between the wild type and the variant alleles for single-nucleotide polymorphism tested as percentages of nonresponders (3435CC = 17.5% vs 3435CT/3435TT = 15.8%, P = .85; 2677GG = 17.8% vs 2677GT/2677TT = 15.8%, P = .74) or pain ratings. Conclusion: No association was found between the tested single-nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone.

U2 - 10.1177/0091270010397729

DO - 10.1177/0091270010397729

M3 - Journal article

VL - 52

SP - 234

EP - 242

JO - The Journal of Clinical Pharmacology

JF - The Journal of Clinical Pharmacology

SN - 0091-2700

IS - 2

ER -