Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism?

T Watt, Laszlo Hegedüs , J B Bjorner, M Groenvold, Steen Joop Bonnema, Rasmussen Å K, Ulla Feldt-Rasmussen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE: To evaluate the relationship between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO.

METHODS: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism were analyzed in relation to thyroid volume, thyroid function and markers of thyroid autoimmunity. Based on a classical QoL framework, we hypothesized that physiological dysfunction caused specific physical and psychological symptoms, which affected functioning and well-being, and consequently participation in life and QoL. These hypotheses were tested through multiple regression and multivariate path analysis models.

RESULTS: None of the thyroid function tests were associated with QoL scores. However, in the pairwise regression, the thyroid peroxidase antibody (TPOAb) level was associated with several QoL outcomes: Goitre Symptoms (p = 0.024), Depressivity (p = 0.004), Anxiety (p = 0.004), Emotional Susceptibility (p = 0.005) and Impaired Social Life (p = 0.047). In the multivariate model, the TPOAb level was related to Goitre Symptoms (r = 0.17, p = 0.019), Depressivity (r = 0.24, p = 0.001), and Anxiety (r = 0.23, p = 0.002), but no longer to Emotional Susceptibility or Impaired Social Life, indicating that the effect on these were mediated through an effect on the symptom scales (i.e. Goitre Symptoms, Depressivity and Anxiety).

CONCLUSION: Health-related QoL, evaluated with state-of-the-art QoL methodology, was related to TPOAb level but not to thyroid function. This raises the hypothesis that autoimmunity, independent of thyroid function, impacts on QoL in patients with autoimmune hypothyroidism, especially in terms of psychological symptoms. Longitudinal studies, in initially untreated patients, are needed to test this hypothesis.

Original languageEnglish
JournalEuropean Thyroid Journal
Volume1
Issue number3
Pages (from-to)186-192
ISSN2235-0640
DOIs
Publication statusPublished - 2012

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Autoimmunity
Quality of Life
Iodide Peroxidase
Autoimmune Hypothyroidism
Longitudinal Studies
Outpatients
Multivariate Analysis
Cross-Sectional Studies

Cite this

Watt, T ; Hegedüs , Laszlo ; Bjorner, J B ; Groenvold, M ; Bonnema, Steen Joop ; Å K, Rasmussen ; Feldt-Rasmussen, Ulla. / Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism?. In: European Thyroid Journal. 2012 ; Vol. 1, No. 3. pp. 186-192.
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title = "Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism?",
abstract = "PURPOSE: To evaluate the relationship between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO.METHODS: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism were analyzed in relation to thyroid volume, thyroid function and markers of thyroid autoimmunity. Based on a classical QoL framework, we hypothesized that physiological dysfunction caused specific physical and psychological symptoms, which affected functioning and well-being, and consequently participation in life and QoL. These hypotheses were tested through multiple regression and multivariate path analysis models.RESULTS: None of the thyroid function tests were associated with QoL scores. However, in the pairwise regression, the thyroid peroxidase antibody (TPOAb) level was associated with several QoL outcomes: Goitre Symptoms (p = 0.024), Depressivity (p = 0.004), Anxiety (p = 0.004), Emotional Susceptibility (p = 0.005) and Impaired Social Life (p = 0.047). In the multivariate model, the TPOAb level was related to Goitre Symptoms (r = 0.17, p = 0.019), Depressivity (r = 0.24, p = 0.001), and Anxiety (r = 0.23, p = 0.002), but no longer to Emotional Susceptibility or Impaired Social Life, indicating that the effect on these were mediated through an effect on the symptom scales (i.e. Goitre Symptoms, Depressivity and Anxiety).CONCLUSION: Health-related QoL, evaluated with state-of-the-art QoL methodology, was related to TPOAb level but not to thyroid function. This raises the hypothesis that autoimmunity, independent of thyroid function, impacts on QoL in patients with autoimmune hypothyroidism, especially in terms of psychological symptoms. Longitudinal studies, in initially untreated patients, are needed to test this hypothesis.",
author = "T Watt and Laszlo Heged{\"u}s and Bjorner, {J B} and M Groenvold and Bonnema, {Steen Joop} and {{\AA} K}, Rasmussen and Ulla Feldt-Rasmussen",
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Watt, T, Hegedüs , L, Bjorner, JB, Groenvold, M, Bonnema, SJ, Å K, R & Feldt-Rasmussen, U 2012, 'Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism?', European Thyroid Journal, vol. 1, no. 3, pp. 186-192. https://doi.org/10.1159/000342623

Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism? / Watt, T; Hegedüs , Laszlo; Bjorner, J B; Groenvold, M; Bonnema, Steen Joop; Å K, Rasmussen; Feldt-Rasmussen, Ulla.

In: European Thyroid Journal, Vol. 1, No. 3, 2012, p. 186-192.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Is thyroid autoimmunity per se a determinant of quality of life in patients with autoimmune hypothyroidism?

AU - Watt, T

AU - Hegedüs , Laszlo

AU - Bjorner, J B

AU - Groenvold, M

AU - Bonnema, Steen Joop

AU - Å K, Rasmussen

AU - Feldt-Rasmussen, Ulla

PY - 2012

Y1 - 2012

N2 - PURPOSE: To evaluate the relationship between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO.METHODS: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism were analyzed in relation to thyroid volume, thyroid function and markers of thyroid autoimmunity. Based on a classical QoL framework, we hypothesized that physiological dysfunction caused specific physical and psychological symptoms, which affected functioning and well-being, and consequently participation in life and QoL. These hypotheses were tested through multiple regression and multivariate path analysis models.RESULTS: None of the thyroid function tests were associated with QoL scores. However, in the pairwise regression, the thyroid peroxidase antibody (TPOAb) level was associated with several QoL outcomes: Goitre Symptoms (p = 0.024), Depressivity (p = 0.004), Anxiety (p = 0.004), Emotional Susceptibility (p = 0.005) and Impaired Social Life (p = 0.047). In the multivariate model, the TPOAb level was related to Goitre Symptoms (r = 0.17, p = 0.019), Depressivity (r = 0.24, p = 0.001), and Anxiety (r = 0.23, p = 0.002), but no longer to Emotional Susceptibility or Impaired Social Life, indicating that the effect on these were mediated through an effect on the symptom scales (i.e. Goitre Symptoms, Depressivity and Anxiety).CONCLUSION: Health-related QoL, evaluated with state-of-the-art QoL methodology, was related to TPOAb level but not to thyroid function. This raises the hypothesis that autoimmunity, independent of thyroid function, impacts on QoL in patients with autoimmune hypothyroidism, especially in terms of psychological symptoms. Longitudinal studies, in initially untreated patients, are needed to test this hypothesis.

AB - PURPOSE: To evaluate the relationship between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO.METHODS: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism were analyzed in relation to thyroid volume, thyroid function and markers of thyroid autoimmunity. Based on a classical QoL framework, we hypothesized that physiological dysfunction caused specific physical and psychological symptoms, which affected functioning and well-being, and consequently participation in life and QoL. These hypotheses were tested through multiple regression and multivariate path analysis models.RESULTS: None of the thyroid function tests were associated with QoL scores. However, in the pairwise regression, the thyroid peroxidase antibody (TPOAb) level was associated with several QoL outcomes: Goitre Symptoms (p = 0.024), Depressivity (p = 0.004), Anxiety (p = 0.004), Emotional Susceptibility (p = 0.005) and Impaired Social Life (p = 0.047). In the multivariate model, the TPOAb level was related to Goitre Symptoms (r = 0.17, p = 0.019), Depressivity (r = 0.24, p = 0.001), and Anxiety (r = 0.23, p = 0.002), but no longer to Emotional Susceptibility or Impaired Social Life, indicating that the effect on these were mediated through an effect on the symptom scales (i.e. Goitre Symptoms, Depressivity and Anxiety).CONCLUSION: Health-related QoL, evaluated with state-of-the-art QoL methodology, was related to TPOAb level but not to thyroid function. This raises the hypothesis that autoimmunity, independent of thyroid function, impacts on QoL in patients with autoimmune hypothyroidism, especially in terms of psychological symptoms. Longitudinal studies, in initially untreated patients, are needed to test this hypothesis.

U2 - 10.1159/000342623

DO - 10.1159/000342623

M3 - Journal article

VL - 1

SP - 186

EP - 192

JO - European Thyroid Journal

JF - European Thyroid Journal

SN - 2235-0640

IS - 3

ER -