Is the Number of Different MRI Findings More Strongly Associated with Low Back Pain Than Single MRI Findings?

Mark J Hancock, Per Kjaer, Peter Kent, Rikke K Jensen, Tue S Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

STUDY DESIGN: A cross-sectional and longitudinal analysis using 2 different data sets OBJECTIVE.: To investigate if the number of different MRI findings present is more strongly associated with low back pain (LBP) than single MRI findings.

SUMMARY OF BACKGROUND DATA: Most previous studies have investigated the associations between single MRI findings and back pain rather than investigating combinations of MRI findings. If different individuals have different pathoanatomic sources contributing to their pain, then combinations of MRI findings may be more strongly associated with LBP.

METHODS: This study used data from two previous studies that investigated the association between single MRI findings and LBP. One study was a cross-sectional population cohort of 412 forty-year old people, the second was a longitudinal cohort of 76 people recently recovered from LBP who were followed for 12 months. The outcome for the cross-sectional study was presence of LBP during the last year. The outcome for the longitudinal study was days to recurrence of activity limiting LBP. In both data sets we created an aggregate score of the number of different MRI findings present in each individual and assessed the relationship between this aggregate score and LBP.

RESULTS: The risk of LBP outcome increased with increasing numbers of different MRI findings. Compared to those with no MRI findings, those with 3 MRI findings were at substantially greater risk of LBP in the last year (Odd Ratio = 14.1; 95%CI 4.32 to 49.47) in the cross-sectional study, or of future recurrence of LBP (Hazard Ratio = 12.2; 95%CI 1.26 to 118.21) in the longitudinal study.

CONCLUSIONS: The aggregate MRI score was more strongly associated with LBP outcomes than single MRI findings in both data sets. Further investigation of this approach is indicated.

LEVEL OF EVIDENCE: 2.

Original languageEnglish
JournalSpine
Volume42
Issue number17
Pages (from-to)1283–1288
ISSN0362-2436
DOIs
Publication statusPublished - 2017

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Low Back Pain
Cross-Sectional Studies
Longitudinal Studies
Odds Ratio
Outcome Assessment (Health Care)

Cite this

@article{d36f48e341c14073ade42c3fe929ed37,
title = "Is the Number of Different MRI Findings More Strongly Associated with Low Back Pain Than Single MRI Findings?",
abstract = "STUDY DESIGN: A cross-sectional and longitudinal analysis using 2 different data sets OBJECTIVE.: To investigate if the number of different MRI findings present is more strongly associated with low back pain (LBP) than single MRI findings.SUMMARY OF BACKGROUND DATA: Most previous studies have investigated the associations between single MRI findings and back pain rather than investigating combinations of MRI findings. If different individuals have different pathoanatomic sources contributing to their pain, then combinations of MRI findings may be more strongly associated with LBP.METHODS: This study used data from two previous studies that investigated the association between single MRI findings and LBP. One study was a cross-sectional population cohort of 412 forty-year old people, the second was a longitudinal cohort of 76 people recently recovered from LBP who were followed for 12 months. The outcome for the cross-sectional study was presence of LBP during the last year. The outcome for the longitudinal study was days to recurrence of activity limiting LBP. In both data sets we created an aggregate score of the number of different MRI findings present in each individual and assessed the relationship between this aggregate score and LBP.RESULTS: The risk of LBP outcome increased with increasing numbers of different MRI findings. Compared to those with no MRI findings, those with 3 MRI findings were at substantially greater risk of LBP in the last year (Odd Ratio = 14.1; 95{\%}CI 4.32 to 49.47) in the cross-sectional study, or of future recurrence of LBP (Hazard Ratio = 12.2; 95{\%}CI 1.26 to 118.21) in the longitudinal study.CONCLUSIONS: The aggregate MRI score was more strongly associated with LBP outcomes than single MRI findings in both data sets. Further investigation of this approach is indicated.LEVEL OF EVIDENCE: 2.",
author = "Hancock, {Mark J} and Per Kjaer and Peter Kent and Jensen, {Rikke K} and Jensen, {Tue S}",
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Is the Number of Different MRI Findings More Strongly Associated with Low Back Pain Than Single MRI Findings? / Hancock, Mark J; Kjaer, Per; Kent, Peter; Jensen, Rikke K; Jensen, Tue S.

In: Spine, Vol. 42, No. 17, 2017, p. 1283–1288.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Is the Number of Different MRI Findings More Strongly Associated with Low Back Pain Than Single MRI Findings?

AU - Hancock, Mark J

AU - Kjaer, Per

AU - Kent, Peter

AU - Jensen, Rikke K

AU - Jensen, Tue S

PY - 2017

Y1 - 2017

N2 - STUDY DESIGN: A cross-sectional and longitudinal analysis using 2 different data sets OBJECTIVE.: To investigate if the number of different MRI findings present is more strongly associated with low back pain (LBP) than single MRI findings.SUMMARY OF BACKGROUND DATA: Most previous studies have investigated the associations between single MRI findings and back pain rather than investigating combinations of MRI findings. If different individuals have different pathoanatomic sources contributing to their pain, then combinations of MRI findings may be more strongly associated with LBP.METHODS: This study used data from two previous studies that investigated the association between single MRI findings and LBP. One study was a cross-sectional population cohort of 412 forty-year old people, the second was a longitudinal cohort of 76 people recently recovered from LBP who were followed for 12 months. The outcome for the cross-sectional study was presence of LBP during the last year. The outcome for the longitudinal study was days to recurrence of activity limiting LBP. In both data sets we created an aggregate score of the number of different MRI findings present in each individual and assessed the relationship between this aggregate score and LBP.RESULTS: The risk of LBP outcome increased with increasing numbers of different MRI findings. Compared to those with no MRI findings, those with 3 MRI findings were at substantially greater risk of LBP in the last year (Odd Ratio = 14.1; 95%CI 4.32 to 49.47) in the cross-sectional study, or of future recurrence of LBP (Hazard Ratio = 12.2; 95%CI 1.26 to 118.21) in the longitudinal study.CONCLUSIONS: The aggregate MRI score was more strongly associated with LBP outcomes than single MRI findings in both data sets. Further investigation of this approach is indicated.LEVEL OF EVIDENCE: 2.

AB - STUDY DESIGN: A cross-sectional and longitudinal analysis using 2 different data sets OBJECTIVE.: To investigate if the number of different MRI findings present is more strongly associated with low back pain (LBP) than single MRI findings.SUMMARY OF BACKGROUND DATA: Most previous studies have investigated the associations between single MRI findings and back pain rather than investigating combinations of MRI findings. If different individuals have different pathoanatomic sources contributing to their pain, then combinations of MRI findings may be more strongly associated with LBP.METHODS: This study used data from two previous studies that investigated the association between single MRI findings and LBP. One study was a cross-sectional population cohort of 412 forty-year old people, the second was a longitudinal cohort of 76 people recently recovered from LBP who were followed for 12 months. The outcome for the cross-sectional study was presence of LBP during the last year. The outcome for the longitudinal study was days to recurrence of activity limiting LBP. In both data sets we created an aggregate score of the number of different MRI findings present in each individual and assessed the relationship between this aggregate score and LBP.RESULTS: The risk of LBP outcome increased with increasing numbers of different MRI findings. Compared to those with no MRI findings, those with 3 MRI findings were at substantially greater risk of LBP in the last year (Odd Ratio = 14.1; 95%CI 4.32 to 49.47) in the cross-sectional study, or of future recurrence of LBP (Hazard Ratio = 12.2; 95%CI 1.26 to 118.21) in the longitudinal study.CONCLUSIONS: The aggregate MRI score was more strongly associated with LBP outcomes than single MRI findings in both data sets. Further investigation of this approach is indicated.LEVEL OF EVIDENCE: 2.

U2 - 10.1097/BRS.0000000000002102

DO - 10.1097/BRS.0000000000002102

M3 - Journal article

C2 - 28169955

VL - 42

SP - 1283

EP - 1288

JO - Spine

JF - Spine

SN - 0362-2436

IS - 17

ER -