Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity? A study within the Danish National Birth Cohort

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Abstract

Background Obesity among women may influence the risk of degenerative musculoskeletal conditions (MSCs) and contribute to poor quality of life. Parity, which constitutes a sudden natural increase in weight as well it affects long-term body mass index (BMI), may put strain on the musculoskeletal system. The interplay between pre-pregnancy BMI and parity and the risk of MSC is unknown. Aim We conducted this study to examine how pre-pregnancy BMI and parity were associated with long-term risk of MSCs. Methods From the Danish National Birth Cohort, 79,687 mothers with singleton births were included. Information on height and weight prior to pregnancy was obtained from telephone interviews and parity from the Danish Medical Birth Registry. Diagnoses on degenerative MSC including osteoarthritis, disc disorders, low back pain, and soft tissue disorders were obtained from the National Patient Registry. Hazard ratios (HR) were estimated using Cox regression, adjusting for relevant confounders including maternal age. The follow-up started at the day of conception. Results The cumulative incidence of MSCs during a median follow-up of 12.4 years was 19.7%. Risk of MSC increased with both increasing pre-pregnancy BMI and parity. Women, obese prior to conception, had an increased risk of 26% of development of MSCs compared to a normal-weight woman [95% confidence interval 19-34%]. HR of Compared to normal-weight first time mothers, the highest risk was seen in obese women with >2 parities (HR 1.61 [95% confidence interval 1.41-1.83]). Conclusions High pre-pregnancy BMI increased the occurrence of degenerative MSC in the years following pregnancy and childbirth. In combination with increasing pre-pregnancy BMI, higher parity added to an already elevated risk. Prevention of maternal overweight may reduce the development of degenerative MSCs among mothers.
Original languageEnglish
Publication date27. Aug 2015
Number of pages1
Publication statusPublished - 27. Aug 2015
EventNOrdic Congress on Obesity in Gynaecology and Obestetrics - Hindsgavl Conference Center, Middelfart, Denmark
Duration: 27. Aug 201529. Aug 2015
Conference number: 2

Conference

ConferenceNOrdic Congress on Obesity in Gynaecology and Obestetrics
Number2
LocationHindsgavl Conference Center
CountryDenmark
CityMiddelfart
Period27/08/201529/08/2015

Fingerprint

Parity
Body Mass Index
Mothers
Weights and Measures
Registries
Confidence Intervals
Musculoskeletal System
Population Growth
Maternal Age
Low Back Pain
Quality of Life
Interviews
Incidence

Keywords

  • Pre-pregnancy BMI
  • Pregnancy-related weight changes
  • Degenerative musculo-skeletal diseases

Cite this

@conference{99ba86d569bb47ff9c9ec1d4f264da7c,
title = "Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity?: A study within the Danish National Birth Cohort",
abstract = "Background Obesity among women may influence the risk of degenerative musculoskeletal conditions (MSCs) and contribute to poor quality of life. Parity, which constitutes a sudden natural increase in weight as well it affects long-term body mass index (BMI), may put strain on the musculoskeletal system. The interplay between pre-pregnancy BMI and parity and the risk of MSC is unknown. Aim We conducted this study to examine how pre-pregnancy BMI and parity were associated with long-term risk of MSCs. Methods From the Danish National Birth Cohort, 79,687 mothers with singleton births were included. Information on height and weight prior to pregnancy was obtained from telephone interviews and parity from the Danish Medical Birth Registry. Diagnoses on degenerative MSC including osteoarthritis, disc disorders, low back pain, and soft tissue disorders were obtained from the National Patient Registry. Hazard ratios (HR) were estimated using Cox regression, adjusting for relevant confounders including maternal age. The follow-up started at the day of conception. Results The cumulative incidence of MSCs during a median follow-up of 12.4 years was 19.7{\%}. Risk of MSC increased with both increasing pre-pregnancy BMI and parity. Women, obese prior to conception, had an increased risk of 26{\%} of development of MSCs compared to a normal-weight woman [95{\%} confidence interval 19-34{\%}]. HR of Compared to normal-weight first time mothers, the highest risk was seen in obese women with >2 parities (HR 1.61 [95{\%} confidence interval 1.41-1.83]). Conclusions High pre-pregnancy BMI increased the occurrence of degenerative MSC in the years following pregnancy and childbirth. In combination with increasing pre-pregnancy BMI, higher parity added to an already elevated risk. Prevention of maternal overweight may reduce the development of degenerative MSCs among mothers.",
keywords = "Pre-pregnancy BMI, Pregnancy-related weight changes, Degenerative musculo-skeletal diseases",
author = "Mette Bliddal and Anton Potteg{\aa}rd and Helene Kirkegaard and J{\o}rn Olsen and J{\o}rgensen, {Jan Stener} and S{\o}rensen, {Thorkild I.} and Lene Dreyer and N{\o}hr, {Ellen Aagaard}",
year = "2015",
month = "8",
day = "27",
language = "English",
note = "NOrdic Congress on Obesity in Gynaecology and Obestetrics , NOCOGO 2015 ; Conference date: 27-08-2015 Through 29-08-2015",

}

Bliddal, M, Pottegård, A, Kirkegaard, H, Olsen, J, Jørgensen, JS, Sørensen, TI, Dreyer, L & Nøhr, EA 2015, 'Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity? A study within the Danish National Birth Cohort ', NOrdic Congress on Obesity in Gynaecology and Obestetrics , Middelfart, Denmark, 27/08/2015 - 29/08/2015.

Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity? A study within the Danish National Birth Cohort . / Bliddal, Mette; Pottegård, Anton; Kirkegaard, Helene; Olsen, Jørn; Jørgensen, Jan Stener; Sørensen, Thorkild I.; Dreyer, Lene; Nøhr, Ellen Aagaard .

2015. Poster session presented at NOrdic Congress on Obesity in Gynaecology and Obestetrics , Middelfart, Denmark.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

TY - CONF

T1 - Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity?

T2 - A study within the Danish National Birth Cohort

AU - Bliddal, Mette

AU - Pottegård, Anton

AU - Kirkegaard, Helene

AU - Olsen, Jørn

AU - Jørgensen, Jan Stener

AU - Sørensen, Thorkild I.

AU - Dreyer, Lene

AU - Nøhr, Ellen Aagaard

PY - 2015/8/27

Y1 - 2015/8/27

N2 - Background Obesity among women may influence the risk of degenerative musculoskeletal conditions (MSCs) and contribute to poor quality of life. Parity, which constitutes a sudden natural increase in weight as well it affects long-term body mass index (BMI), may put strain on the musculoskeletal system. The interplay between pre-pregnancy BMI and parity and the risk of MSC is unknown. Aim We conducted this study to examine how pre-pregnancy BMI and parity were associated with long-term risk of MSCs. Methods From the Danish National Birth Cohort, 79,687 mothers with singleton births were included. Information on height and weight prior to pregnancy was obtained from telephone interviews and parity from the Danish Medical Birth Registry. Diagnoses on degenerative MSC including osteoarthritis, disc disorders, low back pain, and soft tissue disorders were obtained from the National Patient Registry. Hazard ratios (HR) were estimated using Cox regression, adjusting for relevant confounders including maternal age. The follow-up started at the day of conception. Results The cumulative incidence of MSCs during a median follow-up of 12.4 years was 19.7%. Risk of MSC increased with both increasing pre-pregnancy BMI and parity. Women, obese prior to conception, had an increased risk of 26% of development of MSCs compared to a normal-weight woman [95% confidence interval 19-34%]. HR of Compared to normal-weight first time mothers, the highest risk was seen in obese women with >2 parities (HR 1.61 [95% confidence interval 1.41-1.83]). Conclusions High pre-pregnancy BMI increased the occurrence of degenerative MSC in the years following pregnancy and childbirth. In combination with increasing pre-pregnancy BMI, higher parity added to an already elevated risk. Prevention of maternal overweight may reduce the development of degenerative MSCs among mothers.

AB - Background Obesity among women may influence the risk of degenerative musculoskeletal conditions (MSCs) and contribute to poor quality of life. Parity, which constitutes a sudden natural increase in weight as well it affects long-term body mass index (BMI), may put strain on the musculoskeletal system. The interplay between pre-pregnancy BMI and parity and the risk of MSC is unknown. Aim We conducted this study to examine how pre-pregnancy BMI and parity were associated with long-term risk of MSCs. Methods From the Danish National Birth Cohort, 79,687 mothers with singleton births were included. Information on height and weight prior to pregnancy was obtained from telephone interviews and parity from the Danish Medical Birth Registry. Diagnoses on degenerative MSC including osteoarthritis, disc disorders, low back pain, and soft tissue disorders were obtained from the National Patient Registry. Hazard ratios (HR) were estimated using Cox regression, adjusting for relevant confounders including maternal age. The follow-up started at the day of conception. Results The cumulative incidence of MSCs during a median follow-up of 12.4 years was 19.7%. Risk of MSC increased with both increasing pre-pregnancy BMI and parity. Women, obese prior to conception, had an increased risk of 26% of development of MSCs compared to a normal-weight woman [95% confidence interval 19-34%]. HR of Compared to normal-weight first time mothers, the highest risk was seen in obese women with >2 parities (HR 1.61 [95% confidence interval 1.41-1.83]). Conclusions High pre-pregnancy BMI increased the occurrence of degenerative MSC in the years following pregnancy and childbirth. In combination with increasing pre-pregnancy BMI, higher parity added to an already elevated risk. Prevention of maternal overweight may reduce the development of degenerative MSCs among mothers.

KW - Pre-pregnancy BMI

KW - Pregnancy-related weight changes

KW - Degenerative musculo-skeletal diseases

M3 - Poster

ER -

Bliddal M, Pottegård A, Kirkegaard H, Olsen J, Jørgensen JS, Sørensen TI et al. Is risk of degenerative musculoskeletal conditions associated with pre-pregnancy body mass index and parity? A study within the Danish National Birth Cohort . 2015. Poster session presented at NOrdic Congress on Obesity in Gynaecology and Obestetrics , Middelfart, Denmark.