Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment

Robin Christensen, Henning Bliddal

Research output: Contribution to journalEditorialResearchpeer-review

Abstract

A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above 0.5 is rarely seen. Despite our concerns about the fact that trial registration took place after the study was completed and the likelihood that patients would note the taste of fish, a circumstance that would lead to detection bias, we consider these data promising though with a high risk of bias.
Original languageEnglish
JournalArthritis Research & Therapy
Volume12
Issue number1
Pages (from-to)105
ISSN1478-6362
DOIs
Publication statusPublished - 1. Jan 2010

Keywords

  • Bias (Epidemiology)
  • Dietary Supplements
  • Fish Oils
  • Humans
  • Osteoarthritis
  • Randomized Controlled Trials as Topic
  • Urtica dioica
  • Vitamin E
  • Zinc

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