Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?

Christian Sonne, Rune Dietz, Erik W Born, Frank F Riget, Maja Kirkegaard, Lars Hyldstrup, Robert J Letcher, Derek C G Muir

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure.
Original languageEnglish
JournalEnvironmental Health Perspectives
Volume112
Issue number17
Pages (from-to)1711-6
Number of pages5
ISSN0091-6765
Publication statusPublished - 1. Dec 2004
Externally publishedYes

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Greenland
Minerals
Bone Density
Halogenated Diphenyl Ethers
Dieldrin
Chlordan
Hexachlorobenzene
Lumbar Vertebrae

Cite this

Sonne, C., Dietz, R., Born, E. W., Riget, F. F., Kirkegaard, M., Hyldstrup, L., ... Muir, D. C. G. (2004). Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? Environmental Health Perspectives, 112(17), 1711-6.
Sonne, Christian ; Dietz, Rune ; Born, Erik W ; Riget, Frank F ; Kirkegaard, Maja ; Hyldstrup, Lars ; Letcher, Robert J ; Muir, Derek C G. / Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?. In: Environmental Health Perspectives. 2004 ; Vol. 112, No. 17. pp. 1711-6.
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title = "Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?",
abstract = "We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure.",
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Sonne, C, Dietz, R, Born, EW, Riget, FF, Kirkegaard, M, Hyldstrup, L, Letcher, RJ & Muir, DCG 2004, 'Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?', Environmental Health Perspectives, vol. 112, no. 17, pp. 1711-6.

Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? / Sonne, Christian; Dietz, Rune; Born, Erik W; Riget, Frank F; Kirkegaard, Maja; Hyldstrup, Lars; Letcher, Robert J; Muir, Derek C G.

In: Environmental Health Perspectives, Vol. 112, No. 17, 01.12.2004, p. 1711-6.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?

AU - Sonne, Christian

AU - Dietz, Rune

AU - Born, Erik W

AU - Riget, Frank F

AU - Kirkegaard, Maja

AU - Hyldstrup, Lars

AU - Letcher, Robert J

AU - Muir, Derek C G

PY - 2004/12/1

Y1 - 2004/12/1

N2 - We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure.

AB - We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure.

M3 - Journal article

VL - 112

SP - 1711

EP - 1716

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 17

ER -

Sonne C, Dietz R, Born EW, Riget FF, Kirkegaard M, Hyldstrup L et al. Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? Environmental Health Perspectives. 2004 Dec 1;112(17):1711-6.