Is a constant low-entropy process at the root of glycolytic oscillations?

Henrik Seir Thoke, Lars Folke Olsen, Lars Duelund, Roberto P. Stock , Thomas Heimburg, Luis Bagatolli

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Abstract

We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.
Original languageEnglish
JournalJournal of Biological Physics
Volume44
Issue number3
Pages (from-to)419-431
ISSN0092-0606
DOIs
Publication statusPublished - Sep 2018

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Entropy
entropy
oscillations
thermodynamics
metabolites
yeast
heat flux
formalism
requirements

Keywords

  • Association-induction hypothesis
  • Glycolytic oscillations
  • Isentropic process
  • Onsager’s theory
  • Temperature oscillations
  • Thermodynamics
  • Models, Biological
  • Glycolysis
  • Entropy
  • Hot Temperature
  • Saccharomyces cerevisiae/physiology

Cite this

Thoke, Henrik Seir ; Olsen, Lars Folke ; Duelund, Lars ; Stock , Roberto P. ; Heimburg, Thomas ; Bagatolli, Luis. / Is a constant low-entropy process at the root of glycolytic oscillations?. In: Journal of Biological Physics. 2018 ; Vol. 44, No. 3. pp. 419-431.
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title = "Is a constant low-entropy process at the root of glycolytic oscillations?",
abstract = "We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.",
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Is a constant low-entropy process at the root of glycolytic oscillations? / Thoke, Henrik Seir; Olsen, Lars Folke; Duelund, Lars; Stock , Roberto P.; Heimburg, Thomas; Bagatolli, Luis.

In: Journal of Biological Physics, Vol. 44, No. 3, 09.2018, p. 419-431.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Is a constant low-entropy process at the root of glycolytic oscillations?

AU - Thoke, Henrik Seir

AU - Olsen, Lars Folke

AU - Duelund, Lars

AU - Stock , Roberto P.

AU - Heimburg, Thomas

AU - Bagatolli, Luis

PY - 2018/9

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AB - We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.

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KW - Isentropic process

KW - Onsager’s theory

KW - Temperature oscillations

KW - Thermodynamics

KW - Models, Biological

KW - Glycolysis

KW - Entropy

KW - Hot Temperature

KW - Saccharomyces cerevisiae/physiology

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