Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

Translated title of the contribution: Integrated diagnostics of brain tumours based on histological and molecular features

Jeanette Krogh Petersen, David Scheie, Henning Boldt, Benedicte Parm Ulhøi, Marianne Schmidt Ettrup, Bjarne Winther Kristensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A considerable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute “integrated diagnoses”. The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.
Translated title of the contributionIntegrated diagnostics of brain tumours based on histological and molecular features
Original languageDanish
Article numberV07180509
JournalUgeskrift for Laeger
Volume181
Issue number21
ISSN0041-5782
Publication statusPublished - 2019

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