Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project

Marta Benet, Richard Albang, Mariona Pinart, Cynthia Hohmann, Christina G Tischer, Isabella Annesi-Maesano, Nour Baïz, Carsten Bindslev-Jensen, Karin C Lødrup Carlsen, Kai-Hakon Carlsen, Lourdes Cirugeda, Esben Eller, Maria Pia Fantini, Ulrike Gehring, Beatrix Gerhard, Davide Gori, Eva Hallner, Inger Kull, Jacopo Lenzi, Rosemary McEachanEleonora Minina, Isabelle Momas, Silvia Narduzzi, Emily S Petherick, Daniela Porta, Fanny Rancière, Marie Standl, Maties Torrent, Alet H Wijga, John Wright, Manolis Kogevinas, Stefano Guerra, Jordi Sunyer, Thomas Keil, Jean Bousquet, Dieter Maier, Josep M Anto, Judith Garcia-Aymerich

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Abstract

The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume188
Issue number2
Pages (from-to)408–417
ISSN0002-9262
DOIs
Publication statusPublished - Feb 2019

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Keywords

  • allergy
  • asthma
  • birth cohorts
  • data accuracy
  • data harmonization
  • data pooling
  • data sharing

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Benet, Marta ; Albang, Richard ; Pinart, Mariona ; Hohmann, Cynthia ; Tischer, Christina G ; Annesi-Maesano, Isabella ; Baïz, Nour ; Bindslev-Jensen, Carsten ; Lødrup Carlsen, Karin C ; Carlsen, Kai-Hakon ; Cirugeda, Lourdes ; Eller, Esben ; Fantini, Maria Pia ; Gehring, Ulrike ; Gerhard, Beatrix ; Gori, Davide ; Hallner, Eva ; Kull, Inger ; Lenzi, Jacopo ; McEachan, Rosemary ; Minina, Eleonora ; Momas, Isabelle ; Narduzzi, Silvia ; Petherick, Emily S ; Porta, Daniela ; Rancière, Fanny ; Standl, Marie ; Torrent, Maties ; Wijga, Alet H ; Wright, John ; Kogevinas, Manolis ; Guerra, Stefano ; Sunyer, Jordi ; Keil, Thomas ; Bousquet, Jean ; Maier, Dieter ; Anto, Josep M ; Garcia-Aymerich, Judith. / Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project. In: American Journal of Epidemiology. 2019 ; Vol. 188, No. 2. pp. 408–417.
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abstract = "The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70{\%}, 15{\%}, and 15{\%} of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.",
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Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, CG, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, KC, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, MP, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, ES, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, AH, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, JM & Garcia-Aymerich, J 2019, 'Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417. https://doi.org/10.1093/aje/kwy242

Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project. / Benet, Marta; Albang, Richard; Pinart, Mariona; Hohmann, Cynthia; Tischer, Christina G; Annesi-Maesano, Isabella; Baïz, Nour; Bindslev-Jensen, Carsten; Lødrup Carlsen, Karin C; Carlsen, Kai-Hakon; Cirugeda, Lourdes; Eller, Esben; Fantini, Maria Pia; Gehring, Ulrike; Gerhard, Beatrix; Gori, Davide; Hallner, Eva; Kull, Inger; Lenzi, Jacopo; McEachan, Rosemary; Minina, Eleonora; Momas, Isabelle; Narduzzi, Silvia; Petherick, Emily S; Porta, Daniela; Rancière, Fanny; Standl, Marie; Torrent, Maties; Wijga, Alet H; Wright, John; Kogevinas, Manolis; Guerra, Stefano; Sunyer, Jordi; Keil, Thomas; Bousquet, Jean; Maier, Dieter; Anto, Josep M; Garcia-Aymerich, Judith.

In: American Journal of Epidemiology, Vol. 188, No. 2, 02.2019, p. 408–417.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts

T2 - A Harmonization Study in the Mechanisms of the Development of Allergy Project

AU - Benet, Marta

AU - Albang, Richard

AU - Pinart, Mariona

AU - Hohmann, Cynthia

AU - Tischer, Christina G

AU - Annesi-Maesano, Isabella

AU - Baïz, Nour

AU - Bindslev-Jensen, Carsten

AU - Lødrup Carlsen, Karin C

AU - Carlsen, Kai-Hakon

AU - Cirugeda, Lourdes

AU - Eller, Esben

AU - Fantini, Maria Pia

AU - Gehring, Ulrike

AU - Gerhard, Beatrix

AU - Gori, Davide

AU - Hallner, Eva

AU - Kull, Inger

AU - Lenzi, Jacopo

AU - McEachan, Rosemary

AU - Minina, Eleonora

AU - Momas, Isabelle

AU - Narduzzi, Silvia

AU - Petherick, Emily S

AU - Porta, Daniela

AU - Rancière, Fanny

AU - Standl, Marie

AU - Torrent, Maties

AU - Wijga, Alet H

AU - Wright, John

AU - Kogevinas, Manolis

AU - Guerra, Stefano

AU - Sunyer, Jordi

AU - Keil, Thomas

AU - Bousquet, Jean

AU - Maier, Dieter

AU - Anto, Josep M

AU - Garcia-Aymerich, Judith

PY - 2019/2

Y1 - 2019/2

N2 - The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

AB - The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

KW - allergy

KW - asthma

KW - birth cohorts

KW - data accuracy

KW - data harmonization

KW - data pooling

KW - data sharing

U2 - 10.1093/aje/kwy242

DO - 10.1093/aje/kwy242

M3 - Journal article

C2 - 30351340

VL - 188

SP - 408

EP - 417

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

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