Abstract
Polycystic ovary syndrome (PCOS) affects 5-8% of fertile women and is often accompanied by insulin resistance, leading to increased risk of developing type 2 diabetes. Skeletal muscle from insulin-resistant PCOS subjects display reduced expression of nuclear encoded genes involved in mitochondrial oxidative metabolism.
Original language | English |
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Journal | The Journal of Clinical Endocrinology & Metabolism |
Volume | 96 |
Issue number | 8 |
Pages (from-to) | E1298-302 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Adaptation, Physiological
- Adenosine Triphosphate
- Adult
- Cells, Cultured
- Female
- Glucose Clamp Technique
- Humans
- Hyperinsulinism
- Insulin Resistance
- Mitochondria
- Mitochondrial Diseases
- Muscle Fibers, Skeletal
- Oxidative Phosphorylation
- Polycystic Ovary Syndrome