TY - JOUR
T1 - Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
AU - Orrù, Stefania
AU - Imperlini, Esther
AU - Vitucci, Daniela
AU - Caterino, Marianna
AU - Mandola, Annalisa
AU - Randers, Morten Bredsgaard
AU - Schmidt, Jakob Friis
AU - Hagman, Marie
AU - Andersen, Thomas Rostgaard
AU - Krustrup, Peter
AU - Ruoppolo, Margherita
AU - Buono, Pasqualina
AU - Mancini, Annamaria
PY - 2022/12
Y1 - 2022/12
N2 - Background: Aging and sedentary behavior are independent risk factors for non-communicablediseases. An active lifestyle and structured physical activity are positively associated with a healthierquality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signatureinduced by lifelong football training associated with successful aging. Methods: The study wasperformed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects.We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained datawere analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelongfootball training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fattyacids as preferential energetic substrates and hence determining a healthier body composition andmetabolic profile; furthermore, we showed that the total polyamine content is higher in lifelongfootball players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.Conclusions: Lifelong football training, as a structured physical activity, significantly influences theexpression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophyassociated with successful aging
AB - Background: Aging and sedentary behavior are independent risk factors for non-communicablediseases. An active lifestyle and structured physical activity are positively associated with a healthierquality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signatureinduced by lifelong football training associated with successful aging. Methods: The study wasperformed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects.We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained datawere analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelongfootball training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fattyacids as preferential energetic substrates and hence determining a healthier body composition andmetabolic profile; furthermore, we showed that the total polyamine content is higher in lifelongfootball players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.Conclusions: Lifelong football training, as a structured physical activity, significantly influences theexpression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophyassociated with successful aging
U2 - 10.3390/ijerph192315835
DO - 10.3390/ijerph192315835
M3 - Journal article
C2 - 36497910
SN - 1661-7827
VL - 19
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 23
M1 - 15835
ER -