Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering

Wiebke Reichstein; Levke Sommer; Salih Veziroglu; Selin Sayin; Stefan Schröder; Yogendra Kumar Mishra; Eyüp İlker Saygili; Fatih Karayürek; Yahya Açil; Jörg Wiltfang; Aydin Gülses; Franz Faupel; Oral Cenk Aktas

doi:10.3390/polym13020186

Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering

Wiebke Reichstein, Levke Sommer, Salih Veziroglu, Selin Sayin, Stefan Schröder, Yogendra Kumar Mishra, Eyüp İlker Saygili, Fatih Karayürek, Yahya Açil, Jörg Wiltfang, Aydin Gülses^*, Franz Faupel, Oral Cenk Aktas

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

88 Downloads (Pure)

Abstract

The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP–PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.

Original language	English
Article number	186
Journal	Polymers
Volume	13
Issue number	2
Number of pages	11
ISSN	2073-4360
DOIs	https://doi.org/10.3390/polym13020186
Publication status	Published - 2. Jan 2021

Keywords

Biocompatibility
Hydrogel
ICVD
Osteoblast
PLA
Proliferation
Tissue engineering

Documents & Links

10.3390/polym13020186Licence: CC BY

Open Access VersionFinal published version, 4.74 MBLicence: CC BY

Cite this

Reichstein, W., Sommer, L., Veziroglu, S., Sayin, S., Schröder, S., Mishra, Y. K., Saygili, E. İ., Karayürek, F., Açil, Y., Wiltfang, J., Gülses, A., Faupel, F., & Aktas, O. C. (2021). Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering. Polymers, 13(2), [186]. https://doi.org/10.3390/polym13020186

@article{d745c5d29c3b40ec89be33a62344f7f6,

title = "Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering",

abstract = "The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP–PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.",

keywords = "Biocompatibility, Hydrogel, ICVD, Osteoblast, PLA, Proliferation, Tissue engineering",

author = "Wiebke Reichstein and Levke Sommer and Salih Veziroglu and Selin Sayin and Stefan Schr{\"o}der and Mishra, {Yogendra Kumar} and Saygili, {Ey{\"u}p İlker} and Fatih Karay{\"u}rek and Yahya A{\c c}il and J{\"o}rg Wiltfang and Aydin G{\"u}lses and Franz Faupel and Aktas, {Oral Cenk}",

note = "Funding Information: Funding: This research was funded by the German Research Foundation (DFG) within the frame of Research Training Group “Materials4Brain” (RTG2154). Publisher Copyright: {\textcopyright} 2021 by the authors. Li-censee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

day = "2",

doi = "10.3390/polym13020186",

language = "English",

volume = "13",

journal = "Polymers",

issn = "2073-4360",

publisher = "MDPI",

number = "2",

}

Reichstein, W, Sommer, L, Veziroglu, S, Sayin, S, Schröder, S, Mishra, YK, Saygili, Eİ, Karayürek, F, Açil, Y, Wiltfang, J, Gülses, A, Faupel, F & Aktas, OC 2021, 'Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering', Polymers, vol. 13, no. 2, 186. https://doi.org/10.3390/polym13020186

TY - JOUR

T1 - Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering

AU - Reichstein, Wiebke

AU - Sommer, Levke

AU - Veziroglu, Salih

AU - Sayin, Selin

AU - Schröder, Stefan

AU - Mishra, Yogendra Kumar

AU - Saygili, Eyüp İlker

AU - Karayürek, Fatih

AU - Açil, Yahya

AU - Wiltfang, Jörg

AU - Gülses, Aydin

AU - Faupel, Franz

AU - Aktas, Oral Cenk

N1 - Funding Information: Funding: This research was funded by the German Research Foundation (DFG) within the frame of Research Training Group “Materials4Brain” (RTG2154). Publisher Copyright: © 2021 by the authors. Li-censee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/2

Y1 - 2021/1/2

N2 - The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP–PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.

AB - The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP–PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.

KW - Biocompatibility

KW - Hydrogel

KW - ICVD

KW - Osteoblast

KW - PLA

KW - Proliferation

KW - Tissue engineering

U2 - 10.3390/polym13020186

DO - 10.3390/polym13020186

M3 - Journal article

C2 - 33430187

AN - SCOPUS:85099121997

SN - 2073-4360

VL - 13

JO - Polymers

JF - Polymers

IS - 2

M1 - 186

ER -

Initiated chemical vapor deposition (Icvd) functionalized polylactic acid–marine algae composite patch for bone tissue engineering

Abstract

Keywords

Documents & Links

Fingerprint

Cite this