Influence of abnormal glucose metabolism on coronary microvascular function after a recent myocardial infarction

Brian B Løgstrup, Dan E Høfsten, Thomas B Christophersen, Jacob E Møller, Hans E Bøtker, Patricia A Pellikka, Kenneth Egstrup

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVES: This study sought to assess the association between abnormal glucose metabolism and abnormal coronary flow reserve (CFR) in patients with a recent acute myocardial infarction (AMI). BACKGROUND: Mortality and morbidity after AMI is high among patients with abnormal glucose metabolism, which may be related to abnormal microcirculation. METHODS: We studied 183 patients with a first AMI. In 161 patients with no history of diabetes mellitus (DM), an oral glucose tolerance test was performed, and patients were categorized according to World Health Organization criteria for whole blood glucose into 3 groups. After coronary angiography and revascularization, a comprehensive transthoracic echocardiogram and noninvasive assessment of CFR was performed in the distal part of left descending artery, as an indicator of microvascular function. Adenosine was administered by intravenous infusion (140 microg/kg/min) to obtain the hyperemic flow profiles. The CFR was defined as the ratio of hyperemic to baseline peak diastolic coronary flow velocities. RESULTS: Median CFR was 1.9 (interquartile range [IQR] 1.4 to 2.4], and 109 (60%) patients had a CFR
Original languageEnglish
JournalJACC - Cardiovascular Imaging
Volume2
Issue number10
Pages (from-to)1159-66
Number of pages7
ISSN1936-878X
DOIs
Publication statusPublished - 1. Oct 2009

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