Increased T-regulatory cells within lymphocyte follicles in moderate COPD

J. Plumb, L. J. C. Smyth, H. R. Adams, J. Vestbo, A. Bentley, S. D. Singh

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue specific follicles has not been investigated. The presence of CD4+FOXP3+ T-regulatory cells was assessed in surgically resected lung tissue from 12 COPD patients, 11 smokers with normal lung function and seven nonsmokers by combined immunofluorescence and immunohistochemistry. Organised lymphoid follicles were observed in all three groups of patients, as well as lymphoid clusters lacking organisation. The percentage of CD4 cells that were T-regulatory cells were significantly increased (p=0.02) within COPD (16%) follicles compared with smokers (10%) and nonsmokers (8%). In contrast, there was no change (p>0.05) in the percentage of T-regulatory cells in clusters or the subepithelium between groups. Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles. Copyright©ERS Journals Ltd 2009.
Original languageEnglish
JournalEuropean Respiratory Journal
Volume34
Issue number1
Pages (from-to)89-94
Number of pages6
ISSN0903-1936
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

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Chronic Obstructive Pulmonary Disease
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Plumb, J. ; Smyth, L. J. C. ; Adams, H. R. ; Vestbo, J. ; Bentley, A. ; Singh, S. D. / Increased T-regulatory cells within lymphocyte follicles in moderate COPD. In: European Respiratory Journal. 2009 ; Vol. 34, No. 1. pp. 89-94.
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abstract = "Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue specific follicles has not been investigated. The presence of CD4+FOXP3+ T-regulatory cells was assessed in surgically resected lung tissue from 12 COPD patients, 11 smokers with normal lung function and seven nonsmokers by combined immunofluorescence and immunohistochemistry. Organised lymphoid follicles were observed in all three groups of patients, as well as lymphoid clusters lacking organisation. The percentage of CD4 cells that were T-regulatory cells were significantly increased (p=0.02) within COPD (16{\%}) follicles compared with smokers (10{\%}) and nonsmokers (8{\%}). In contrast, there was no change (p>0.05) in the percentage of T-regulatory cells in clusters or the subepithelium between groups. Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles. Copyright{\circledC}ERS Journals Ltd 2009.",
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Increased T-regulatory cells within lymphocyte follicles in moderate COPD. / Plumb, J.; Smyth, L. J. C.; Adams, H. R.; Vestbo, J.; Bentley, A.; Singh, S. D.

In: European Respiratory Journal, Vol. 34, No. 1, 07.2009, p. 89-94.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Increased T-regulatory cells within lymphocyte follicles in moderate COPD

AU - Plumb, J.

AU - Smyth, L. J. C.

AU - Adams, H. R.

AU - Vestbo, J.

AU - Bentley, A.

AU - Singh, S. D.

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Y1 - 2009/7

N2 - Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue specific follicles has not been investigated. The presence of CD4+FOXP3+ T-regulatory cells was assessed in surgically resected lung tissue from 12 COPD patients, 11 smokers with normal lung function and seven nonsmokers by combined immunofluorescence and immunohistochemistry. Organised lymphoid follicles were observed in all three groups of patients, as well as lymphoid clusters lacking organisation. The percentage of CD4 cells that were T-regulatory cells were significantly increased (p=0.02) within COPD (16%) follicles compared with smokers (10%) and nonsmokers (8%). In contrast, there was no change (p>0.05) in the percentage of T-regulatory cells in clusters or the subepithelium between groups. Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles. Copyright©ERS Journals Ltd 2009.

AB - Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue specific follicles has not been investigated. The presence of CD4+FOXP3+ T-regulatory cells was assessed in surgically resected lung tissue from 12 COPD patients, 11 smokers with normal lung function and seven nonsmokers by combined immunofluorescence and immunohistochemistry. Organised lymphoid follicles were observed in all three groups of patients, as well as lymphoid clusters lacking organisation. The percentage of CD4 cells that were T-regulatory cells were significantly increased (p=0.02) within COPD (16%) follicles compared with smokers (10%) and nonsmokers (8%). In contrast, there was no change (p>0.05) in the percentage of T-regulatory cells in clusters or the subepithelium between groups. Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles. Copyright©ERS Journals Ltd 2009.

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KW - Smokers

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