Increased plasma concentration of serum amyloid P component in centenarians with impaired cognitive performance

M Nybo, H Olsen, B Jeune, K Andersen-Ranberg, E Holm Nielsen, S E Svehag

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Serum amyloid P component (SAP) binds to all amyloid fibrils including those in the plaques and tangles of Alzheimer patients. To investigate whether the plasma SAP concentration correlated to cognitive impairment, we measured SAP levels in blood samples from 41 centenarians and compared these to the cognitive performance evaluated by Mini Mental State Examination (MMSE). We observed a significantly (p < 0.001) increased SAP concentration (48.3+/-16.9 microg/ml; mean +/- SD) in the centenarians compared to gender-matched controls (32.8+/-11.4 microg/ml). Six severely demented centenarians had an even higher SAP concentration (60.2 microg/ml), while the subgroup of cognitive intact centenarians (MMSE score >24) showed a normal SAP concentration (38.4+/-9.3 microg/ml). No dehydration or hepatic dysfunction was demonstrable in the centenarians. We conclude that the centenarians with impaired cognitive performance had significantly increased plasma concentrations of SAP, while the values for cognitive intact centenarians were within the normal range.
Original languageEnglish
JournalDementia and Geriatric Cognitive Disorders
Volume9
Issue number3
Pages (from-to)126-129
Number of pages3
ISSN1420-8008
Publication statusPublished - 1998

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Cognition Disorders
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Reference Values
  • Serum Amyloid P-Component

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