Increased incidence of genital warts among women and men with type 1 diabetes compared with the general population—results from a nationwide registry-based, cohort study

K. Reinholdt, C. Munk, L. T. Thomsen, C. Dehlendorff, B. Carstensen, M. E. Jørgensen, S. K. Kjaer*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aims: To estimate the incidence rates of genital warts (GWs) in women and men with type 1 diabetes compared to persons without diabetes. Methods: In this nationwide registry-based cohort study, we included the entire population aged 15 to 49 years living in Denmark between 1996 and 2016. From national registries, we retrieved individual level information on diabetes status, diagnoses and treatment of GWs, and potential confounding variables. We used Poisson regression to model sex- and age-specific incidence rates of GWs in persons with type 1 diabetes and persons without diabetes. Based on the models, we computed sex-specific incidence rate ratios (IRRs) of GWs in persons with type 1 diabetes compared to persons without diabetes, overall and according to age. Results: The analysis included 3,514,824 persons without type 2 diabetes and no GW diagnoses before baseline. The incidence rate of GWs in persons with type 1 diabetes was higher than in those without diabetes, both among women (IRR = 1.59; 95% CI, 1.42–1.78) and men (IRR = 1.36; 95% CI, 1.25–1.48). The pattern of increased incidence rates of GWs in persons with type 1 diabetes was seen at all ages. Conclusions: Persons with type 1 diabetes have higher incidence rates of GWs than persons without diabetes. This supports the importance of HPV vaccination of young girls and boys with type 1 diabetes.

Original languageEnglish
JournalActa Diabetologica
Volume59
Issue number1
Pages (from-to)105-112
ISSN0940-5429
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

Publisher Copyright:
© 2021, Springer-Verlag Italia S.r.l., part of Springer Nature.

Keywords

  • Genital warts
  • Human papillomavirus
  • Nationwide cohort
  • Type 1 diabetes
  • Humans
  • Male
  • Diabetes Mellitus, Type 1/complications
  • Incidence
  • Female
  • Registries
  • Condylomata Acuminata/epidemiology
  • Diabetes Mellitus, Type 2
  • Cohort Studies

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