Increased concordance of severe respiratory syncytial virus infection in identical twins

Simon Francis Thomsen, Lone Graff Stensballe, Axel Skytthe, Kirsten Ohm Kyvik, Vibeke Backer, Hans Bisgaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.
Original languageEnglish
JournalPediatrics
Volume121
Issue number3
Pages (from-to)493-496
Number of pages3
ISSN0031-4005
DOIs
Publication statusPublished - 1. Mar 2008

Keywords

  • Age Distribution
  • Antigens, Viral
  • Child, Preschool
  • Confidence Intervals
  • Denmark
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Infant
  • Male
  • Probability
  • Proportional Hazards Models
  • Registries
  • Respiratory Syncytial Virus Infections
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Sex Distribution
  • Twins, Monozygotic

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