Increased concordance of severe respiratory syncytial virus infection in identical twins

Simon Francis Thomsen, Lone Graff Stensballe, Axel Skytthe, Kirsten Ohm Kyvik, Vibeke Backer, Hans Bisgaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.
Original languageEnglish
JournalPediatrics
Volume121
Issue number3
Pages (from-to)493-496
Number of pages3
ISSN0031-4005
DOIs
Publication statusPublished - 1 Mar 2008

Fingerprint

Respiratory Syncytial Virus Infections
Monozygotic Twins
Dizygotic Twins
Respiratory Syncytial Viruses
Information Storage and Retrieval
Genetic Models
Denmark
Genetic Markers

Keywords

  • Age Distribution
  • Antigens, Viral
  • Child, Preschool
  • Confidence Intervals
  • Denmark
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Infant
  • Male
  • Probability
  • Proportional Hazards Models
  • Registries
  • Respiratory Syncytial Virus Infections
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Sex Distribution
  • Twins, Monozygotic

Cite this

Thomsen, Simon Francis ; Stensballe, Lone Graff ; Skytthe, Axel ; Kyvik, Kirsten Ohm ; Backer, Vibeke ; Bisgaard, Hans. / Increased concordance of severe respiratory syncytial virus infection in identical twins. In: Pediatrics. 2008 ; Vol. 121, No. 3. pp. 493-496.
@article{c93fab40411311dd9fbe000ea68e967b,
title = "Increased concordance of severe respiratory syncytial virus infection in identical twins",
abstract = "OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16{\%}, family environment for 73{\%}, and nonshared environment for 11{\%} of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.",
keywords = "Age Distribution, Antigens, Viral, Child, Preschool, Confidence Intervals, Denmark, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Incidence, Infant, Male, Probability, Proportional Hazards Models, Registries, Respiratory Syncytial Virus Infections, Retrospective Studies, Risk Factors, Severity of Illness Index, Sex Distribution, Twins, Monozygotic",
author = "Thomsen, {Simon Francis} and Stensballe, {Lone Graff} and Axel Skytthe and Kyvik, {Kirsten Ohm} and Vibeke Backer and Hans Bisgaard",
year = "2008",
month = "3",
day = "1",
doi = "10.1542/peds.2007-1889",
language = "English",
volume = "121",
pages = "493--496",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "3",

}

Increased concordance of severe respiratory syncytial virus infection in identical twins. / Thomsen, Simon Francis; Stensballe, Lone Graff; Skytthe, Axel; Kyvik, Kirsten Ohm; Backer, Vibeke; Bisgaard, Hans.

In: Pediatrics, Vol. 121, No. 3, 01.03.2008, p. 493-496.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Increased concordance of severe respiratory syncytial virus infection in identical twins

AU - Thomsen, Simon Francis

AU - Stensballe, Lone Graff

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Backer, Vibeke

AU - Bisgaard, Hans

PY - 2008/3/1

Y1 - 2008/3/1

N2 - OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

AB - OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors. METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods. RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection. CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

KW - Age Distribution

KW - Antigens, Viral

KW - Child, Preschool

KW - Confidence Intervals

KW - Denmark

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Probability

KW - Proportional Hazards Models

KW - Registries

KW - Respiratory Syncytial Virus Infections

KW - Retrospective Studies

KW - Risk Factors

KW - Severity of Illness Index

KW - Sex Distribution

KW - Twins, Monozygotic

U2 - 10.1542/peds.2007-1889

DO - 10.1542/peds.2007-1889

M3 - Journal article

VL - 121

SP - 493

EP - 496

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 3

ER -