Increased alanine aminotransferase levels and associated characteristics among newly diagnosed type 2 diabetes patients: Results from the DD2 study

Anil Mor, Reimar W. Thomsen, Jørgen Rungby, Sinna Pilgaard Ulrichsen, Jens Steen Nielsen, Jacob Stidsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen6, Henning Beck-Nielsen, Henrik Toft Sørensen

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Objectives: Elevated levels of serum alanine aminotransferase (ALAT) have been linked with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), insulin resistance and the metabolic syndrome in type 2 diabetes (T2D) patients. We examined ALAT levels in newly diagnosed T2D patients, and the factors associated with such elevation.
Methods: Measurements of ALAT were performed in 1,025 (43% women; 57% men) new T2D patients enrolled from general practitioners and hospital specialist outpatient clinics in the nationwide DD2 project. We calculated the median value of ALAT, and examined the number of T2D patients within gender specific quartiles of ALAT values. We also examined demographic, clinical, and lifestyle characteristics associated with increased ALAT levels. Data on BMI, lipid profile and blood pressure could be ascertained from the Danish Diabetes Database for Adults for a subgroup (n=525) of the study population.
Results: The median value of ALAT was 24IU/L (inter-quartile range 18-32IU/L) in women and 30IU/L (inter-quartile range 22-41IU/L) in men. 26% were in the lowest ALAT quartile (<18IU/L for women and <22IU/L for men, respectively) and 24% were in the highest ALAT quartile (>32IU/L / >41IU/L for women/men). As compared to people with ALAT values in the lowest quartile, those with high ALAT were younger (median age 57 vs. 64 years, p<0.0001), more obese (median BMI 31.2 vs. 29.1 kg/m2, p=0.004), and had a larger waist circumference (111 vs. 101 cm, p<0.0001) and higher median CRP levels (2.8 vs. 1.8 mg/L, p=0.0147). They also had substantially poorer glucose control (HbA1c 7.40 vs. 6.90%, p=0.084; fasting blood glucose 7.56 vs. 6.86 mmol/L, p<0.0001), and a worse lipid profile (total-cholesterol 4.70 vs. 4.15 mmol/L, p=0.006), whereas blood pressure was similar between groups. Patients in the highest ALAT quartile had more alcohol overuse (10.4% vs. 2.2% with >14/21 weekly drinks in women/men, p<0.0001) as compared to subjects in the lowest quartile.
Conclusions: Among newly diagnosed T2D patients, those with a high ALAT level were younger, had more abdominal obesity, dyslipidemia, poorer glucose control, more alcohol overuse, and higher CRP levels as compared with those in the lowest ALAT quartile
Original languageEnglish
Publication dateApr 2013
Publication statusPublished - Apr 2013
Eventeuropean congres of endocrinology - Bella, Copenhagen, Denmark
Duration: 27. Apr 20131. May 2013


Conferenceeuropean congres of endocrinology

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