Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption

A Linneberg, N Friedrich, L L N Husemoen, B Thuesen, A Gonzalez-Quintela, C Vidal, Uffe Bødtger, N Johansen, T Drivsholm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response.

OBJECTIVES: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization.

METHODS: In 1976-1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay.

RESULTS: We observed a total of 32 (7.1% of those not sensitized at 40 years) incident cases and 35 (41.1% of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization.

CONCLUSIONS: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.

Original languageEnglish
JournalInternational Archives of Allergy and Immunology
Volume151
Issue number2
Pages (from-to)142-8
Number of pages7
ISSN1018-2438
DOIs
Publication statusPublished - 2010

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Alcohol Drinking
Incidence
Allergens
Serum
Immunoassay
Alcohols
Health
Population

Keywords

  • Adult
  • Air Pollutants
  • Alcohol Drinking
  • Allergens
  • Denmark
  • Female
  • Follow-Up Studies
  • Humans
  • Hypersensitivity, Immediate
  • Immunoglobulin E
  • Incidence
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Remission, Spontaneous
  • Risk Factors
  • Sex Factors

Cite this

Linneberg, A ; Friedrich, N ; Husemoen, L L N ; Thuesen, B ; Gonzalez-Quintela, A ; Vidal, C ; Bødtger, Uffe ; Johansen, N ; Drivsholm, T. / Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption. In: International Archives of Allergy and Immunology. 2010 ; Vol. 151, No. 2. pp. 142-8.
@article{6b592b0111ee4d2a84d7257198be969c,
title = "Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption",
abstract = "BACKGROUND: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response.OBJECTIVES: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization.METHODS: In 1976-1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay.RESULTS: We observed a total of 32 (7.1{\%} of those not sensitized at 40 years) incident cases and 35 (41.1{\%} of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization.CONCLUSIONS: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.",
keywords = "Adult, Air Pollutants, Alcohol Drinking, Allergens, Denmark, Female, Follow-Up Studies, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Incidence, Male, Middle Aged, Odds Ratio, Prevalence, Remission, Spontaneous, Risk Factors, Sex Factors",
author = "A Linneberg and N Friedrich and Husemoen, {L L N} and B Thuesen and A Gonzalez-Quintela and C Vidal and Uffe B{\o}dtger and N Johansen and T Drivsholm",
note = "2009 S. Karger AG, Basel.",
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Linneberg, A, Friedrich, N, Husemoen, LLN, Thuesen, B, Gonzalez-Quintela, A, Vidal, C, Bødtger, U, Johansen, N & Drivsholm, T 2010, 'Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption', International Archives of Allergy and Immunology, vol. 151, no. 2, pp. 142-8. https://doi.org/10.1159/000236004

Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption. / Linneberg, A; Friedrich, N; Husemoen, L L N; Thuesen, B; Gonzalez-Quintela, A; Vidal, C; Bødtger, Uffe; Johansen, N; Drivsholm, T.

In: International Archives of Allergy and Immunology, Vol. 151, No. 2, 2010, p. 142-8.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Incidence and remission of specific IgE aeroallergen sensitization from age of 40 to 60 years, and association with alcohol consumption

AU - Linneberg, A

AU - Friedrich, N

AU - Husemoen, L L N

AU - Thuesen, B

AU - Gonzalez-Quintela, A

AU - Vidal, C

AU - Bødtger, Uffe

AU - Johansen, N

AU - Drivsholm, T

N1 - 2009 S. Karger AG, Basel.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response.OBJECTIVES: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization.METHODS: In 1976-1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay.RESULTS: We observed a total of 32 (7.1% of those not sensitized at 40 years) incident cases and 35 (41.1% of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization.CONCLUSIONS: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.

AB - BACKGROUND: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response.OBJECTIVES: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization.METHODS: In 1976-1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay.RESULTS: We observed a total of 32 (7.1% of those not sensitized at 40 years) incident cases and 35 (41.1% of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization.CONCLUSIONS: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.

KW - Adult

KW - Air Pollutants

KW - Alcohol Drinking

KW - Allergens

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hypersensitivity, Immediate

KW - Immunoglobulin E

KW - Incidence

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Prevalence

KW - Remission, Spontaneous

KW - Risk Factors

KW - Sex Factors

U2 - 10.1159/000236004

DO - 10.1159/000236004

M3 - Journal article

C2 - 19752568

VL - 151

SP - 142

EP - 148

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 2

ER -