Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD): A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD

Victoria Furer*, Christien Rondaan, Marloes Heijstek, Sander Van Assen, Marc Bijl, Nancy Agmon-Levin, Ferdinand C. Breedveld, Raffaele D'Amelio, Maxime Dougados, Meliha Crnkic Kapetanovic, Jacob M. Van Laar, Annette Ladefoged De Thurah, Robert Landewé, Anna Molto, Ulf Müller-Ladner, Karen Schreiber, Leo Smolar, Jim Walker, Klaus Warnatz, Nico M. WulffraatOri Elkayam

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

54 Downloads (Pure)

Abstract

Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was performed when appropriate. Results Sixty-three publications out of 3876 identified records met the inclusion criteria: influenza (n=4), pneumococcal disease (n=7), hepatitis B (n=10), herpes zoster (HZ) (n=29), human papillomavirus (HPV) infection (n=13). An increased incidence of influenza and pneumococcal disease was reported in patients with AIIRD. HZ infection-pooled incidence rate ratio (IRR) was 2.9 (95% CI 2.4 to 3.3) in patients with AIIRD versus general population. Among AIIRD, inflammatory myositis conferred the highest incidence rate (IR) of HZ (pooled IRR 5.1, 95% CI 4.3 to 5.9), followed by systemic lupus erythematosus (SLE) (pooled IRR 4.0, 95% CI 2.3 to 5.7) and rheumatoid arthritis (pooled IRR 2.3, 95% CI 2.1 to 2.6). HPV infection-pooled prevalence ratio was 1.6, 95% CI 0.7 to 3.4 versus general population, based on studies mainly conducted in the SLE population in Latin America and Asia. Pooled prevalence of hepatitis B surface antigen and hepatitis B core antibody in patients with AIIRD was similar to the general population, 3%, 95% CI 1% to 5% and 15%, 95% CI 7% to 26%, respectively. Conclusion Current evidence shows an increased risk of VPI in patients with AIIRD, emphasising that prevention of infections is essential in these patients.

Original languageEnglish
Article numbere001041
JournalRMD Open
Volume5
Issue number2
Number of pages17
ISSN2056-5933
DOIs
Publication statusPublished - 1. Sep 2019

Fingerprint

Rheumatic Diseases
Incidence
Herpes Zoster
Population
Human Influenza
Hepatitis B Antibodies
Myositis
Latin America
Hepatitis B Surface Antigens
Hepatitis B
Libraries
Publications
Meta-Analysis

Keywords

  • autoimmune diseases
  • epidemiology
  • infections
  • vaccination

Cite this

Furer, Victoria ; Rondaan, Christien ; Heijstek, Marloes ; Van Assen, Sander ; Bijl, Marc ; Agmon-Levin, Nancy ; Breedveld, Ferdinand C. ; D'Amelio, Raffaele ; Dougados, Maxime ; Kapetanovic, Meliha Crnkic ; Van Laar, Jacob M. ; Ladefoged De Thurah, Annette ; Landewé, Robert ; Molto, Anna ; Müller-Ladner, Ulf ; Schreiber, Karen ; Smolar, Leo ; Walker, Jim ; Warnatz, Klaus ; Wulffraat, Nico M. ; Elkayam, Ori. / Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) : A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD. In: RMD Open. 2019 ; Vol. 5, No. 2.
@article{d4c31c6160fc44de9048194f05187643,
title = "Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD): A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD",
abstract = "Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was performed when appropriate. Results Sixty-three publications out of 3876 identified records met the inclusion criteria: influenza (n=4), pneumococcal disease (n=7), hepatitis B (n=10), herpes zoster (HZ) (n=29), human papillomavirus (HPV) infection (n=13). An increased incidence of influenza and pneumococcal disease was reported in patients with AIIRD. HZ infection-pooled incidence rate ratio (IRR) was 2.9 (95{\%} CI 2.4 to 3.3) in patients with AIIRD versus general population. Among AIIRD, inflammatory myositis conferred the highest incidence rate (IR) of HZ (pooled IRR 5.1, 95{\%} CI 4.3 to 5.9), followed by systemic lupus erythematosus (SLE) (pooled IRR 4.0, 95{\%} CI 2.3 to 5.7) and rheumatoid arthritis (pooled IRR 2.3, 95{\%} CI 2.1 to 2.6). HPV infection-pooled prevalence ratio was 1.6, 95{\%} CI 0.7 to 3.4 versus general population, based on studies mainly conducted in the SLE population in Latin America and Asia. Pooled prevalence of hepatitis B surface antigen and hepatitis B core antibody in patients with AIIRD was similar to the general population, 3{\%}, 95{\%} CI 1{\%} to 5{\%} and 15{\%}, 95{\%} CI 7{\%} to 26{\%}, respectively. Conclusion Current evidence shows an increased risk of VPI in patients with AIIRD, emphasising that prevention of infections is essential in these patients.",
keywords = "autoimmune diseases, epidemiology, infections, vaccination",
author = "Victoria Furer and Christien Rondaan and Marloes Heijstek and {Van Assen}, Sander and Marc Bijl and Nancy Agmon-Levin and Breedveld, {Ferdinand C.} and Raffaele D'Amelio and Maxime Dougados and Kapetanovic, {Meliha Crnkic} and {Van Laar}, {Jacob M.} and {Ladefoged De Thurah}, Annette and Robert Landew{\'e} and Anna Molto and Ulf M{\"u}ller-Ladner and Karen Schreiber and Leo Smolar and Jim Walker and Klaus Warnatz and Wulffraat, {Nico M.} and Ori Elkayam",
year = "2019",
month = "9",
day = "1",
doi = "10.1136/rmdopen-2019-001041",
language = "English",
volume = "5",
journal = "RMD Open",
issn = "2056-5933",
publisher = "BMJ Group",
number = "2",

}

Furer, V, Rondaan, C, Heijstek, M, Van Assen, S, Bijl, M, Agmon-Levin, N, Breedveld, FC, D'Amelio, R, Dougados, M, Kapetanovic, MC, Van Laar, JM, Ladefoged De Thurah, A, Landewé, R, Molto, A, Müller-Ladner, U, Schreiber, K, Smolar, L, Walker, J, Warnatz, K, Wulffraat, NM & Elkayam, O 2019, 'Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD): A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD', RMD Open, vol. 5, no. 2, e001041. https://doi.org/10.1136/rmdopen-2019-001041

Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) : A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD. / Furer, Victoria; Rondaan, Christien; Heijstek, Marloes; Van Assen, Sander; Bijl, Marc; Agmon-Levin, Nancy; Breedveld, Ferdinand C.; D'Amelio, Raffaele; Dougados, Maxime; Kapetanovic, Meliha Crnkic; Van Laar, Jacob M.; Ladefoged De Thurah, Annette; Landewé, Robert; Molto, Anna; Müller-Ladner, Ulf; Schreiber, Karen; Smolar, Leo; Walker, Jim; Warnatz, Klaus; Wulffraat, Nico M.; Elkayam, Ori.

In: RMD Open, Vol. 5, No. 2, e001041, 01.09.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD)

T2 - A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD

AU - Furer, Victoria

AU - Rondaan, Christien

AU - Heijstek, Marloes

AU - Van Assen, Sander

AU - Bijl, Marc

AU - Agmon-Levin, Nancy

AU - Breedveld, Ferdinand C.

AU - D'Amelio, Raffaele

AU - Dougados, Maxime

AU - Kapetanovic, Meliha Crnkic

AU - Van Laar, Jacob M.

AU - Ladefoged De Thurah, Annette

AU - Landewé, Robert

AU - Molto, Anna

AU - Müller-Ladner, Ulf

AU - Schreiber, Karen

AU - Smolar, Leo

AU - Walker, Jim

AU - Warnatz, Klaus

AU - Wulffraat, Nico M.

AU - Elkayam, Ori

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was performed when appropriate. Results Sixty-three publications out of 3876 identified records met the inclusion criteria: influenza (n=4), pneumococcal disease (n=7), hepatitis B (n=10), herpes zoster (HZ) (n=29), human papillomavirus (HPV) infection (n=13). An increased incidence of influenza and pneumococcal disease was reported in patients with AIIRD. HZ infection-pooled incidence rate ratio (IRR) was 2.9 (95% CI 2.4 to 3.3) in patients with AIIRD versus general population. Among AIIRD, inflammatory myositis conferred the highest incidence rate (IR) of HZ (pooled IRR 5.1, 95% CI 4.3 to 5.9), followed by systemic lupus erythematosus (SLE) (pooled IRR 4.0, 95% CI 2.3 to 5.7) and rheumatoid arthritis (pooled IRR 2.3, 95% CI 2.1 to 2.6). HPV infection-pooled prevalence ratio was 1.6, 95% CI 0.7 to 3.4 versus general population, based on studies mainly conducted in the SLE population in Latin America and Asia. Pooled prevalence of hepatitis B surface antigen and hepatitis B core antibody in patients with AIIRD was similar to the general population, 3%, 95% CI 1% to 5% and 15%, 95% CI 7% to 26%, respectively. Conclusion Current evidence shows an increased risk of VPI in patients with AIIRD, emphasising that prevention of infections is essential in these patients.

AB - Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was performed when appropriate. Results Sixty-three publications out of 3876 identified records met the inclusion criteria: influenza (n=4), pneumococcal disease (n=7), hepatitis B (n=10), herpes zoster (HZ) (n=29), human papillomavirus (HPV) infection (n=13). An increased incidence of influenza and pneumococcal disease was reported in patients with AIIRD. HZ infection-pooled incidence rate ratio (IRR) was 2.9 (95% CI 2.4 to 3.3) in patients with AIIRD versus general population. Among AIIRD, inflammatory myositis conferred the highest incidence rate (IR) of HZ (pooled IRR 5.1, 95% CI 4.3 to 5.9), followed by systemic lupus erythematosus (SLE) (pooled IRR 4.0, 95% CI 2.3 to 5.7) and rheumatoid arthritis (pooled IRR 2.3, 95% CI 2.1 to 2.6). HPV infection-pooled prevalence ratio was 1.6, 95% CI 0.7 to 3.4 versus general population, based on studies mainly conducted in the SLE population in Latin America and Asia. Pooled prevalence of hepatitis B surface antigen and hepatitis B core antibody in patients with AIIRD was similar to the general population, 3%, 95% CI 1% to 5% and 15%, 95% CI 7% to 26%, respectively. Conclusion Current evidence shows an increased risk of VPI in patients with AIIRD, emphasising that prevention of infections is essential in these patients.

KW - autoimmune diseases

KW - epidemiology

KW - infections

KW - vaccination

U2 - 10.1136/rmdopen-2019-001041

DO - 10.1136/rmdopen-2019-001041

M3 - Journal article

C2 - 31673420

AN - SCOPUS:85072211326

VL - 5

JO - RMD Open

JF - RMD Open

SN - 2056-5933

IS - 2

M1 - e001041

ER -