In Patients with Cirrhosis, Driving Simulator Performance is Associated With Real-life Driving

Mette Enok Munk Lauridsen, Leroy R Thacker, Melanie B White, Ariel Unser, Richard K Sterling, Richard T Stravitz, Scott Matherly, Puneet Puri, Arun J Sanyal, Edith A Gavis, Velimir Luketic, Muhammad S Siddiqui, Douglas M Heuman, Michael Fuchs, Jasmohan S Bajaj

Research output: Contribution to journalJournal articleResearchpeer-review


Background & Aims: Minimal hepatic encephalopathy (MHE) has been linked to higher real-life rates of automobile crashes and poor performance in driving simulation studies, but the link between driving simulator performance and real-life automobile crashes has not been clearly established. Furthermore, not all patients with MHE are unsafe drivers, but it is unclear how to distinguish them from unsafe drivers. We investigated the link between performance on driving simulators and real-life automobile accidents and traffic violations. We also aimed to identify features of unsafe drivers with cirrhosis and evaluated changes in simulated driving skills and MHE status after 1 year. Methods: We performed a study of outpatients with cirrhosis (n = 205; median 55 years old; median model for end-stage liver disease score, 9.5; none with overt hepatic encephalopathy or alcohol or illicit drug use within previous 6 months) seen at the Virginia Commonwealth University and McGuire Veterans Administration Medical Center, from November 2008 through April 2014. All participants were given paper-pencil tests to diagnose MHE (98 had MHE; 48%), and 163 patients completed a standardized driving simulation. Data were collected on traffic violations and automobile accidents from the Virginia Department of Motor Vehicles and from participants' self-assessments when they entered the study, and from 73 participants 1 year later. Participants also completed a questionnaire about alcohol use and cessation patterns. The driving simulator measured crashes, run-time, road center and edge excursions, and illegal turns during navigation; before and after each driving simulation session, patients were asked to rate their overall driving skills. Drivers were classified as safe or unsafe based on crashes and violations reported on official driving records; simulation results were compared with real-life driving records. Multivariable regression analyses of real-life crashes and violations was performed using data on demographics, cirrhosis details, MHE status, and alcohol cessation patterns, at baseline and at 1 year. Results: Drivers categorized as unsafe had more crashes and made more illegal turns on the driving simulator than drivers categorized as safe; a higher proportion of subjects with MHE were categorized as unsafe drivers at baseline (16%) than subjects without MHE (7%; P =02), and at 1-year follow-up (18% vs 0%; P =02). Alcohol cessation within <1 year and illegal turns during simulator navigation tasks were associated with real-life automobile crashes and MHE in regression analysis; road edge excursions in the simulator were associated with real-life traffic violations. Personal assessment of driving skills improved after each simulation episode. Conclusions: In a study of 205 patients with cirrhosis, we associated results from driving simulation tests with real-life driving records and MHE. Traffic safety counseling should focus on patients with cirrhosis who recently quit consuming alcohol and perform poorly on driving simulation.

Original languageEnglish
JournalClinical Gastroenterology and Hepatology
Issue number5
Pages (from-to)747–752
Publication statusPublished - May 2016

Bibliographical note

Available online 19 November 2015


  • Car Crash
  • Hepatic Encephalopathy
  • Public Policy
  • Traffic Violation
  • Liver Cirrhosis/complications
  • Prospective Studies
  • Humans
  • Middle Aged
  • Male
  • Accidents, Traffic
  • Young Adult
  • Hepatic Encephalopathy/diagnosis
  • Computer Simulation
  • Adolescent
  • Adult
  • Female
  • Aged
  • Automobile Driving
  • Virginia

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