Improved gait in persons with knee related mobility limitations by a rosehip food supplement: a randomized, double-blind, placebo-controlled trial

Elisabeth Ginnerup-Nielsen, Robin Professor Christensen, Henning Bliddal, Graziella Zangger, Lisbeth Hansen, Marius Henriksen

Research output: Contribution to journalJournal articleResearchpeer-review


Purpose: To evaluate the efficacy of a specialized rosehip powder nutraceutical on the biomechanical function of the knee joint during walking in individuals with knee-related walking limitations. Methods: Randomized, participant and outcome assessor blinded trial. Participants with self-reported knee-related walking limitations were randomized (1:1) to receive three capsules/day of either rosehip powder or identically appearing placebo capsules for 12 weeks. At baseline and the 12 weeks follow-up, 3-dimensional gait analyses were performed from which the peak resultant knee moment was selected as primary outcome. Secondary outcomes included sagittal and frontal plane knee joint moments, knee joint kinematics, peaks in the vertical ground reaction forces, and self-selected walking speeds. Analyses were based on ANCOVA with the 'Intention-To-Treat' (ITT) population, defined as all randomized participants using last observation carried forward imputation for missing data. Results: 100 participants were randomized to rosehip (n= 50) or placebo (n= 50) and defined the ITT population. Of these 94 completed the study (47 in each group). There were statistically significant group differences in the change from baseline in the primary outcome: the resultant knee moment (0.06. nm/kg, 95%CI: 0.00-0.12; P= 0.039) and in the peaks in the sagittal plane moments and kinematics during the stance phase of walking with the rosehip group exhibiting greater joint moments and more knee joint flexion during walking than the placebo group. Conclusion: A daily intake of rosehip powder for 12 weeks improved important indices of knee joint function and dynamics during walking compared to placebo in persons with knee-related walking limitations.

Original languageEnglish
JournalGait & Posture
Issue number3
Pages (from-to)340-347
Publication statusPublished - Jul 2015


  • Dietary supplements
  • Gait
  • Knee pain
  • Randomized trial
  • Double-Blind Method
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Self Report
  • Male
  • Treatment Outcome
  • Rosa
  • Plant Preparations/pharmacology
  • Biomechanical Phenomena
  • Mobility Limitation
  • Walking/physiology
  • Gait/drug effects
  • Aged, 80 and over
  • Adult
  • Female
  • Knee Joint/physiopathology
  • Aged
  • Phytotherapy
  • Dietary Supplements


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