Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Abbas H. K. Al Temimi, Ruben S. Teeuwen, Vu Tran, Arthur J. Altunc, Danny C. Lenstra, Wansheng Ren, Ping Qian, Hong Guo, Jasmin Mecinović*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume17
Issue number23
Pages (from-to)5693-5697
Number of pages5
ISSN1477-0520
DOIs
Publication statusPublished - 2019

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