Impact of socioeconomic status on participation and outcomes in the Salford Lung Studies

Rupert Jones, Andy Nichols, Dominy Browne, Nawar Diar Bakerly, Ashley Woodcock, Jorgen Vestbo, David A Leather, Loretta Jacques, James Lay-Flurrie, Henrik Svedsater, Susan Collier

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Abstract

COPD and asthma prevalence is associated with socioeconomic status (or "deprivation"), yet deprivation is rarely considered in typical large-scale efficacy randomised controlled trials that recruit highly selected patient populations. In this post hoc analysis of the Salford Lung Studies in COPD and asthma (two 12-month, open-label, effectiveness randomised controlled trials conducted in UK primary care), we evaluated the impact of patient deprivation on clinical outcomes with initiating fluticasone furoate/vilanterol versus continuing usual care. Patients were categorised into deprivation quintiles based on postcode and a countrywide database of indices of deprivation, and trial outcomes by quintile were assessed. 52% of patients in the COPD study were included in the most deprived quintile, contrasting with 20% in the asthma study. Greater deprivation was associated with higher rates of primary/secondary healthcare contacts and costs. However, the treatment effect of fluticasone furoate/vilanterol versus usual care for primary (COPD: moderate/severe exacerbations; asthma: Asthma Control Test responders at week 24) and secondary/other (healthcare consumption, adherence, treatment modifications, study withdrawals, exacerbations, serious adverse events) outcomes was similar across deprivation quintiles. Our findings support the recruitment of participants from all socioeconomic strata to allow assessment of data generalisability to routine clinical practice.

Original languageEnglish
Article number00193-2019
JournalERJ Open Research
Volume6
Number of pages9
ISSN2312-0541
DOIs
Publication statusPublished - 1. Jan 2020
Externally publishedYes

Keywords

  • asthma
  • COPD
  • Salford Lung Studies
  • fluticasone
  • furoate/vilanterol
  • effectiveness
  • deprivation

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