Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects

M. Blicher, R. Kruger, Thomas Bastholm Olesen, S. Greve, T. Hansen, M. H. Olsen

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

Objective: We wanted to test the impact of metabolic, hemodynamic and inflammatory factors on target organ damage (TOD) defined as cardiac hypertrophy, atherosclerosis, arterioclerosis and microvascular damage. Design and method: In a population based cohort study of 2115 healthy subjects (1049 male 1066 female) with a mean age of 53.1+/-10.5 without known diabetes or cardiovascular disease we measured fasting plasma glucose (FPG), serum insulin, lipid profile, soluble urokinase receptor (suPAR), c-reactive protein (CRP), urine albumin/creatinine ratio (UACR), 24-hour ambulatory systolic (24hSBP) and diastolic blood pressure (24hDBP), left ventricular mass index (LVMI) by M-mode echocardiography, carotid plaques (CP) by carotid ultra sound and carotid-femoral pulse wave velocity (PWV). To establish best model for association of LVMI, CP, PWV and UACR we used multiple linear regression analysis starting with inclusion of all variables without co-linearity taking away one by one non-significant variables. Results: Cardiac hypertrophy assessed by LVMI was primarily associated with gender (beta = 0.37), 24hSBP (beta = 0.26) and HR (beta = -0.15). Insulin resistance (IR) and inflammation only had minor albeit significant impact on LVMI assessed byHOMA (beta = 0.09) and CRP (beta = 0.05). Atherosclerosis assessed by CP was primarily associated to age (beta = 0.31), 24hSBP (beta = 0.13) and smoking (beta = 0.13). Arteriosclerosis indicated by PWV was primarily associated to age (beta = 0.39), 24hSBP (beta =0.31), gender (beta = 0.14) and HR (beta = 0.15). Additionally, FPG (beta = 0.04), total cholesterol/ high density lipoprotein ratio (TC/HDL) (beta = 0.04) and CRP (beta = 0.03) had positive independent impact on PWV. Microvascular damage assessed by UACR was primarily associated to gender (beta = -0.16), 24hSBP (beta = 0.09) suPAR(beta = 0.09), smoking (beta = 0.05) and age (beta =0.05). Conclusions: We conclude that 24hSBP were independently associated to cardiac hypertrophy, arteriosclerosis, atherosclerosis as well as microvascular damage, whereas IR and inflammation were only weakly, independently associated to hypertrophy, arteriosclerosis and microvascular damage in healthy subjects.
Original languageEnglish
Article number9A.06
JournalJournal of Hypertension
Volume33
Issue numbere-Supplement 1
Pages (from-to)e118
Number of pages1
ISSN0263-6352
DOIs
Publication statusPublished - 2015
Event25th European Meeting on Hypertension and Cardiovascular Protection - Milano, Italy
Duration: 12. Jun 201515. Jun 2015

Conference

Conference25th European Meeting on Hypertension and Cardiovascular Protection
CountryItaly
CityMilano
Period12/06/201515/06/2015

Cite this

@article{d06887a5fec742759e783f6283b063cd,
title = "Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects",
abstract = "Objective: We wanted to test the impact of metabolic, hemodynamic and inflammatory factors on target organ damage (TOD) defined as cardiac hypertrophy, atherosclerosis, arterioclerosis and microvascular damage. Design and method: In a population based cohort study of 2115 healthy subjects (1049 male 1066 female) with a mean age of 53.1+/-10.5 without known diabetes or cardiovascular disease we measured fasting plasma glucose (FPG), serum insulin, lipid profile, soluble urokinase receptor (suPAR), c-reactive protein (CRP), urine albumin/creatinine ratio (UACR), 24-hour ambulatory systolic (24hSBP) and diastolic blood pressure (24hDBP), left ventricular mass index (LVMI) by M-mode echocardiography, carotid plaques (CP) by carotid ultra sound and carotid-femoral pulse wave velocity (PWV). To establish best model for association of LVMI, CP, PWV and UACR we used multiple linear regression analysis starting with inclusion of all variables without co-linearity taking away one by one non-significant variables. Results: Cardiac hypertrophy assessed by LVMI was primarily associated with gender (beta = 0.37), 24hSBP (beta = 0.26) and HR (beta = -0.15). Insulin resistance (IR) and inflammation only had minor albeit significant impact on LVMI assessed byHOMA (beta = 0.09) and CRP (beta = 0.05). Atherosclerosis assessed by CP was primarily associated to age (beta = 0.31), 24hSBP (beta = 0.13) and smoking (beta = 0.13). Arteriosclerosis indicated by PWV was primarily associated to age (beta = 0.39), 24hSBP (beta =0.31), gender (beta = 0.14) and HR (beta = 0.15). Additionally, FPG (beta = 0.04), total cholesterol/ high density lipoprotein ratio (TC/HDL) (beta = 0.04) and CRP (beta = 0.03) had positive independent impact on PWV. Microvascular damage assessed by UACR was primarily associated to gender (beta = -0.16), 24hSBP (beta = 0.09) suPAR(beta = 0.09), smoking (beta = 0.05) and age (beta =0.05). Conclusions: We conclude that 24hSBP were independently associated to cardiac hypertrophy, arteriosclerosis, atherosclerosis as well as microvascular damage, whereas IR and inflammation were only weakly, independently associated to hypertrophy, arteriosclerosis and microvascular damage in healthy subjects.",
keywords = "*target organ *human *normal human *European *hypertension *protection heart ventricle hypertrophy carotid artery arteriosclerosis atherosclerosis gender smoking inflammation cohort analysis glucose blood level multiple linear regression analysis diet restriction insulin blood level pulse wave population cardiovascular disease M mode echocardiography heart left ventricle mass diabetes mellitus diastolic blood pressure ultrasound female model urine male insulin resistance hypertrophy C reactive protein lipid urokinase receptor high density lipoprotein",
author = "M. Blicher and R. Kruger and Olesen, {Thomas Bastholm} and S. Greve and T. Hansen and Olsen, {M. H.}",
year = "2015",
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Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects. / Blicher, M.; Kruger, R.; Olesen, Thomas Bastholm ; Greve, S.; Hansen, T.; Olsen, M. H.

In: Journal of Hypertension, Vol. 33, No. e-Supplement 1, 9A.06, 2015, p. e118.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - Impact of metabolic, hemodynamic and inflammatory factors on target organ damage in healthy subjects

AU - Blicher, M.

AU - Kruger, R.

AU - Olesen, Thomas Bastholm

AU - Greve, S.

AU - Hansen, T.

AU - Olsen, M. H.

PY - 2015

Y1 - 2015

N2 - Objective: We wanted to test the impact of metabolic, hemodynamic and inflammatory factors on target organ damage (TOD) defined as cardiac hypertrophy, atherosclerosis, arterioclerosis and microvascular damage. Design and method: In a population based cohort study of 2115 healthy subjects (1049 male 1066 female) with a mean age of 53.1+/-10.5 without known diabetes or cardiovascular disease we measured fasting plasma glucose (FPG), serum insulin, lipid profile, soluble urokinase receptor (suPAR), c-reactive protein (CRP), urine albumin/creatinine ratio (UACR), 24-hour ambulatory systolic (24hSBP) and diastolic blood pressure (24hDBP), left ventricular mass index (LVMI) by M-mode echocardiography, carotid plaques (CP) by carotid ultra sound and carotid-femoral pulse wave velocity (PWV). To establish best model for association of LVMI, CP, PWV and UACR we used multiple linear regression analysis starting with inclusion of all variables without co-linearity taking away one by one non-significant variables. Results: Cardiac hypertrophy assessed by LVMI was primarily associated with gender (beta = 0.37), 24hSBP (beta = 0.26) and HR (beta = -0.15). Insulin resistance (IR) and inflammation only had minor albeit significant impact on LVMI assessed byHOMA (beta = 0.09) and CRP (beta = 0.05). Atherosclerosis assessed by CP was primarily associated to age (beta = 0.31), 24hSBP (beta = 0.13) and smoking (beta = 0.13). Arteriosclerosis indicated by PWV was primarily associated to age (beta = 0.39), 24hSBP (beta =0.31), gender (beta = 0.14) and HR (beta = 0.15). Additionally, FPG (beta = 0.04), total cholesterol/ high density lipoprotein ratio (TC/HDL) (beta = 0.04) and CRP (beta = 0.03) had positive independent impact on PWV. Microvascular damage assessed by UACR was primarily associated to gender (beta = -0.16), 24hSBP (beta = 0.09) suPAR(beta = 0.09), smoking (beta = 0.05) and age (beta =0.05). Conclusions: We conclude that 24hSBP were independently associated to cardiac hypertrophy, arteriosclerosis, atherosclerosis as well as microvascular damage, whereas IR and inflammation were only weakly, independently associated to hypertrophy, arteriosclerosis and microvascular damage in healthy subjects.

AB - Objective: We wanted to test the impact of metabolic, hemodynamic and inflammatory factors on target organ damage (TOD) defined as cardiac hypertrophy, atherosclerosis, arterioclerosis and microvascular damage. Design and method: In a population based cohort study of 2115 healthy subjects (1049 male 1066 female) with a mean age of 53.1+/-10.5 without known diabetes or cardiovascular disease we measured fasting plasma glucose (FPG), serum insulin, lipid profile, soluble urokinase receptor (suPAR), c-reactive protein (CRP), urine albumin/creatinine ratio (UACR), 24-hour ambulatory systolic (24hSBP) and diastolic blood pressure (24hDBP), left ventricular mass index (LVMI) by M-mode echocardiography, carotid plaques (CP) by carotid ultra sound and carotid-femoral pulse wave velocity (PWV). To establish best model for association of LVMI, CP, PWV and UACR we used multiple linear regression analysis starting with inclusion of all variables without co-linearity taking away one by one non-significant variables. Results: Cardiac hypertrophy assessed by LVMI was primarily associated with gender (beta = 0.37), 24hSBP (beta = 0.26) and HR (beta = -0.15). Insulin resistance (IR) and inflammation only had minor albeit significant impact on LVMI assessed byHOMA (beta = 0.09) and CRP (beta = 0.05). Atherosclerosis assessed by CP was primarily associated to age (beta = 0.31), 24hSBP (beta = 0.13) and smoking (beta = 0.13). Arteriosclerosis indicated by PWV was primarily associated to age (beta = 0.39), 24hSBP (beta =0.31), gender (beta = 0.14) and HR (beta = 0.15). Additionally, FPG (beta = 0.04), total cholesterol/ high density lipoprotein ratio (TC/HDL) (beta = 0.04) and CRP (beta = 0.03) had positive independent impact on PWV. Microvascular damage assessed by UACR was primarily associated to gender (beta = -0.16), 24hSBP (beta = 0.09) suPAR(beta = 0.09), smoking (beta = 0.05) and age (beta =0.05). Conclusions: We conclude that 24hSBP were independently associated to cardiac hypertrophy, arteriosclerosis, atherosclerosis as well as microvascular damage, whereas IR and inflammation were only weakly, independently associated to hypertrophy, arteriosclerosis and microvascular damage in healthy subjects.

KW - target organ human normal human European hypertension protection heart ventricle hypertrophy carotid artery arteriosclerosis atherosclerosis gender smoking inflammation cohort analysis glucose blood level multiple linear regression analysis diet restricti

U2 - 10.1097/01.hjh.0000467669.92026.fa

DO - 10.1097/01.hjh.0000467669.92026.fa

M3 - Conference abstract in journal

VL - 33

SP - e118

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - e-Supplement 1

M1 - 9A.06

ER -