Impact of liver disease on patients' quality of life: a mixed methods systematic review protocol

Lea Ladegaard Grønkjær*, MM Lauridsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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OBJECTIVE: The objective of this systematic review is to explore the impact of liver disease on patients' quality of life in an attempt to develop effective evidence-based recommendations and strategies useful for clinical practice and health care professionals.

INTRODUCTION: Liver diseases are common worldwide and a major cause of illness and death due to health problems and serious complications, which not only cause hospitalization and death, but also emotional distress, depression, and impaired quality of life.

INCLUSION CRITERIA: This review will consider qualitative and quantitative studies on patients with liver disease of different severity and type. The qualitative component of this review will consider all studies that describe patients' lived experience and perception of having liver disease. The quantitative component will include studies that explore the quality of life in patients with liver disease.

METHODS: CINAHL (EBSCO), Embase (Ovid), MEDLINE (Ovid), PsycINFO (Ovid), Scopus (Elsevier), and Web of Science (Ovid) will be searched for articles published in Danish and English without any restriction in terms of year of publication. Articles describing both qualitative and quantitative studies will be screened for inclusion, critically appraised for methodological quality, and have data extracted using JBI instruments for mixed methods systematic reviews. A convergent integrated approach to synthesis and integration will be used.


Original languageEnglish
JournalJBI evidence synthesis
Issue number6
Pages (from-to)1412-1417
Publication statusPublished - Jun 2021


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