Impact of COVID-19 Restrictions on Acute Gastroenteritis in Children: A Regional, Danish, Register-Based Study

Eva Plantener*, Kumanan Rune Nanthan, Ulrik Deding, Mads Damkjær, Ea Sofie Marmolin, Lotte Høeg Hansen, Jens J.H. Petersen, Roberto Pinilla, John E. Coia, Donna Lykke Wolff, Zhijun Song, Ming Chen

*Corresponding author for this work

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This study aimed to evaluate the impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) restrictions such as social distancing on the occurrence of acute gastroenteritis (AGE) among children. This study is a register-based study, including every child seen in the departments of paediatrics with the initial diagnosis of AGE in three neighbouring hospitals in Denmark, from March 2018 through February 2021. The study also included every positive stool sample for AGE-causing pathogens analysed in these three hospitals from children during the same period. The Wilcoxon rank-sum test was used to determine differences between the period during the SARS-CoV-2 restrictions and before. In all, 222,157 children were seen in the three paediatric departments during this period. Of these, 3917 children were diagnosed with AGE. We found a decrease of 46.6% in AGE-related visits per month after the SARS-CoV-2 restrictions were introduced compared to before (p-value < 0.001). Positive stool samples decreased by 38.2% (p-value = 0.008) during the restrictions. This study found that cases of paediatric AGE decreased significantly the during COVID-19 restrictions, suggesting that studies should be conducted to determine whether this reduction was a result of good hand hygiene and social distancing or just a result of altered health-seeking behaviour among children.

Original languageEnglish
Article number816
Issue number5
Number of pages11
Publication statusPublished - 29. Apr 2023

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Publisher Copyright:
© 2023 by the authors.


  • children
  • gastroenteritis
  • paediatrics
  • SARS-CoV-2
  • stool sample


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