Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O'Neill, Christian Weber, Paul C Evans*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

Original languageEnglish
JournalCardiovascular Research
Volume115
Issue number9
Pages (from-to)1385-1392
ISSN0008-6363
DOIs
Publication statusPublished - 15. Jul 2019

Keywords

  • Animals
  • Arteries/immunology
  • Atherosclerosis/immunology
  • Consensus
  • Energy Metabolism/immunology
  • Humans
  • Immune System/immunology
  • Immunomodulation
  • Inflammation Mediators/immunology
  • Inflammation/immunology
  • Macrophages/immunology
  • Monocytes/immunology
  • Plaque, Atherosclerotic
  • Signal Transduction
  • T-Lymphocytes/immunology

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  • Cite this

    Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C., & Evans, P. C. (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research, 115(9), 1385-1392. https://doi.org/10.1093/cvr/cvz166