Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology

Results from an OMERACT Initiative

Sabrina M Nielsen*, Peter Tugwell, Maarten P T de Wit, Maarten Boers, Dorcas E Beaton, Thasia G Woodworth, Reuben Escorpizo, Beverley Shea, Karine Toupin-April, Francis Guillemin, Vibeke Strand, Jasvinder A Singh, Margreet Kloppenburg, Daniel E Furst, George A Wells, Josef S Smolen, Richard Veselý, Annelies Boonen, Helene Storgaard, Marieke Voshaar & 2 others Lyn March, Robin Christensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: The Contextual Factors Working Group aims to provide guidance on addressing contextual factors in rheumatology trials within OMERACT.

METHODS: During the Special Interest Group session at OMERACT 2018, preliminary results were presented from a case scenario survey and semistructured interviews, including contextual factors mentioned in these. A group-based exercise sought to identify and rank important generic contextual factors.

RESULTS: A total of 79 candidate factors were listed. Across the 3 groups, gender/sex, comorbidities, and the healthcare system were ranked as most important.

CONCLUSION: The identified important contextual factor domains may be considered a provisional list pending further research.

Original languageEnglish
JournalJournal of Rheumatology
Volume46
Issue number9
Pages (from-to)1159-1163
ISSN0315-162X
DOIs
Publication statusPublished - Sep 2019

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Public Opinion
Rheumatology
Comorbidity
Clinical Trials
Interviews
Delivery of Health Care
Research
Surveys and Questionnaires

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Nielsen, Sabrina M ; Tugwell, Peter ; de Wit, Maarten P T ; Boers, Maarten ; Beaton, Dorcas E ; Woodworth, Thasia G ; Escorpizo, Reuben ; Shea, Beverley ; Toupin-April, Karine ; Guillemin, Francis ; Strand, Vibeke ; Singh, Jasvinder A ; Kloppenburg, Margreet ; Furst, Daniel E ; Wells, George A ; Smolen, Josef S ; Veselý, Richard ; Boonen, Annelies ; Storgaard, Helene ; Voshaar, Marieke ; March, Lyn ; Christensen, Robin. / Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology : Results from an OMERACT Initiative. In: Journal of Rheumatology. 2019 ; Vol. 46, No. 9. pp. 1159-1163.
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title = "Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology: Results from an OMERACT Initiative",
abstract = "OBJECTIVE: The Contextual Factors Working Group aims to provide guidance on addressing contextual factors in rheumatology trials within OMERACT.METHODS: During the Special Interest Group session at OMERACT 2018, preliminary results were presented from a case scenario survey and semistructured interviews, including contextual factors mentioned in these. A group-based exercise sought to identify and rank important generic contextual factors.RESULTS: A total of 79 candidate factors were listed. Across the 3 groups, gender/sex, comorbidities, and the healthcare system were ranked as most important.CONCLUSION: The identified important contextual factor domains may be considered a provisional list pending further research.",
author = "Nielsen, {Sabrina M} and Peter Tugwell and {de Wit}, {Maarten P T} and Maarten Boers and Beaton, {Dorcas E} and Woodworth, {Thasia G} and Reuben Escorpizo and Beverley Shea and Karine Toupin-April and Francis Guillemin and Vibeke Strand and Singh, {Jasvinder A} and Margreet Kloppenburg and Furst, {Daniel E} and Wells, {George A} and Smolen, {Josef S} and Richard Vesel{\'y} and Annelies Boonen and Helene Storgaard and Marieke Voshaar and Lyn March and Robin Christensen",
year = "2019",
month = "9",
doi = "10.3899/jrheum.181081",
language = "English",
volume = "46",
pages = "1159--1163",
journal = "Journal of Rheumatology",
issn = "0315-162X",
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}

Nielsen, SM, Tugwell, P, de Wit, MPT, Boers, M, Beaton, DE, Woodworth, TG, Escorpizo, R, Shea, B, Toupin-April, K, Guillemin, F, Strand, V, Singh, JA, Kloppenburg, M, Furst, DE, Wells, GA, Smolen, JS, Veselý, R, Boonen, A, Storgaard, H, Voshaar, M, March, L & Christensen, R 2019, 'Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology: Results from an OMERACT Initiative', Journal of Rheumatology, vol. 46, no. 9, pp. 1159-1163. https://doi.org/10.3899/jrheum.181081

Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology : Results from an OMERACT Initiative. / Nielsen, Sabrina M; Tugwell, Peter; de Wit, Maarten P T; Boers, Maarten; Beaton, Dorcas E; Woodworth, Thasia G; Escorpizo, Reuben; Shea, Beverley; Toupin-April, Karine; Guillemin, Francis; Strand, Vibeke; Singh, Jasvinder A; Kloppenburg, Margreet; Furst, Daniel E; Wells, George A; Smolen, Josef S; Veselý, Richard; Boonen, Annelies; Storgaard, Helene; Voshaar, Marieke; March, Lyn; Christensen, Robin.

In: Journal of Rheumatology, Vol. 46, No. 9, 09.2019, p. 1159-1163.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology

T2 - Results from an OMERACT Initiative

AU - Nielsen, Sabrina M

AU - Tugwell, Peter

AU - de Wit, Maarten P T

AU - Boers, Maarten

AU - Beaton, Dorcas E

AU - Woodworth, Thasia G

AU - Escorpizo, Reuben

AU - Shea, Beverley

AU - Toupin-April, Karine

AU - Guillemin, Francis

AU - Strand, Vibeke

AU - Singh, Jasvinder A

AU - Kloppenburg, Margreet

AU - Furst, Daniel E

AU - Wells, George A

AU - Smolen, Josef S

AU - Veselý, Richard

AU - Boonen, Annelies

AU - Storgaard, Helene

AU - Voshaar, Marieke

AU - March, Lyn

AU - Christensen, Robin

PY - 2019/9

Y1 - 2019/9

N2 - OBJECTIVE: The Contextual Factors Working Group aims to provide guidance on addressing contextual factors in rheumatology trials within OMERACT.METHODS: During the Special Interest Group session at OMERACT 2018, preliminary results were presented from a case scenario survey and semistructured interviews, including contextual factors mentioned in these. A group-based exercise sought to identify and rank important generic contextual factors.RESULTS: A total of 79 candidate factors were listed. Across the 3 groups, gender/sex, comorbidities, and the healthcare system were ranked as most important.CONCLUSION: The identified important contextual factor domains may be considered a provisional list pending further research.

AB - OBJECTIVE: The Contextual Factors Working Group aims to provide guidance on addressing contextual factors in rheumatology trials within OMERACT.METHODS: During the Special Interest Group session at OMERACT 2018, preliminary results were presented from a case scenario survey and semistructured interviews, including contextual factors mentioned in these. A group-based exercise sought to identify and rank important generic contextual factors.RESULTS: A total of 79 candidate factors were listed. Across the 3 groups, gender/sex, comorbidities, and the healthcare system were ranked as most important.CONCLUSION: The identified important contextual factor domains may be considered a provisional list pending further research.

U2 - 10.3899/jrheum.181081

DO - 10.3899/jrheum.181081

M3 - Journal article

VL - 46

SP - 1159

EP - 1163

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 9

ER -