Abstract

Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types of cancer such as glioblastoma. We used gene expression data in whole blood from 448 monozygotic twins from the Middle Age Danish Twins (MADT) study to investigate genetic regulation of the MGMT gene by performing a genome-wide association study (GWAS) of the variation in MGMT expression. Additionally, we estimated within-pair dependence measures of the expression values looking for the genetic influence of significant identified genes. We identified 243 single nucleotide polymorphisms (SNPs) significantly (p 
Original languageEnglish
Article number110616
JournalGenomics
Volume115
Issue number3
Number of pages7
ISSN0888-7543
DOIs
Publication statusPublished - 21. Mar 2023

Keywords

  • MGMT
  • Genetic regulation
  • Glioblastoma
  • GWAS
  • Monozygotic twins
  • Genetic contribution

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