Identifying genetic variants regulating MGMT gene expression: A study in monozygotic Danish twins

Afsaneh Mohammadnejad; Mette Sørensen; Jonas Mengel-From; Marianne Nygaard; Maria Timofeeva; Liang He; Signe Bedsted Clemmensen; Ulrich Halekoh; Rikke Hedegaard Dahlrot; Qihua Tan; Jacob Hjelmborg

doi:10.1016/j.ygeno.2023.110616

Identifying genetic variants regulating MGMT gene expression: A study in monozygotic Danish twins

Afsaneh Mohammadnejad^*, Mette Sørensen, Jonas Mengel-From, Marianne Nygaard, Maria Timofeeva, Liang He, Signe Bedsted Clemmensen, Ulrich Halekoh, Rikke Hedegaard Dahlrot, Qihua Tan, Jacob Hjelmborg

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types of cancer such as glioblastoma. We used gene expression data in whole blood from 448 monozygotic twins from the Middle Age Danish Twins (MADT) study to investigate genetic regulation of the MGMT gene by performing a genome-wide association study (GWAS) of the variation in MGMT expression. Additionally, we estimated within-pair dependence measures of the expression values looking for the genetic influence of significant identified genes. We identified 243 single nucleotide polymorphisms (SNPs) significantly (p 

Original language	English
Article number	110616
Journal	Genomics
Volume	115
Issue number	3
Number of pages	7
ISSN	0888-7543
DOIs	https://doi.org/10.1016/j.ygeno.2023.110616
Publication status	Published - 21. Mar 2023

Keywords

MGMT
Genetic regulation
Glioblastoma
GWAS
Monozygotic twins
Genetic contribution

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10.1016/j.ygeno.2023.110616Licence: CC BY

Open Access VersionFinal published version, 2.19 MBLicence: CC BY

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title = "Identifying genetic variants regulating MGMT gene expression: A study in monozygotic Danish twins",

abstract = "Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types of cancer such as glioblastoma. We used gene expression data in whole blood from 448 monozygotic twins from the Middle Age Danish Twins (MADT) study to investigate genetic regulation of the MGMT gene by performing a genome-wide association study (GWAS) of the variation in MGMT expression. Additionally, we estimated within-pair dependence measures of the expression values looking for the genetic influence of significant identified genes. We identified 243 single nucleotide polymorphisms (SNPs) significantly (p ",

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author = "Afsaneh Mohammadnejad and Mette S{\o}rensen and Jonas Mengel-From and Marianne Nygaard and Maria Timofeeva and Liang He and Clemmensen, {Signe Bedsted} and Ulrich Halekoh and Dahlrot, {Rikke Hedegaard} and Qihua Tan and Jacob Hjelmborg",

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T2 - A study in monozygotic Danish twins

AU - Mohammadnejad, Afsaneh

AU - Sørensen, Mette

AU - Mengel-From, Jonas

AU - Nygaard, Marianne

AU - Timofeeva, Maria

AU - He, Liang

AU - Clemmensen, Signe Bedsted

AU - Halekoh, Ulrich

AU - Dahlrot, Rikke Hedegaard

AU - Tan, Qihua

AU - Hjelmborg, Jacob

PY - 2023/3/21

Y1 - 2023/3/21

N2 - Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types of cancer such as glioblastoma. We used gene expression data in whole blood from 448 monozygotic twins from the Middle Age Danish Twins (MADT) study to investigate genetic regulation of the MGMT gene by performing a genome-wide association study (GWAS) of the variation in MGMT expression. Additionally, we estimated within-pair dependence measures of the expression values looking for the genetic influence of significant identified genes. We identified 243 single nucleotide polymorphisms (SNPs) significantly (p 

AB - Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types of cancer such as glioblastoma. We used gene expression data in whole blood from 448 monozygotic twins from the Middle Age Danish Twins (MADT) study to investigate genetic regulation of the MGMT gene by performing a genome-wide association study (GWAS) of the variation in MGMT expression. Additionally, we estimated within-pair dependence measures of the expression values looking for the genetic influence of significant identified genes. We identified 243 single nucleotide polymorphisms (SNPs) significantly (p 

KW - MGMT

KW - Genetic regulation

KW - Glioblastoma

KW - GWAS

KW - Monozygotic twins

KW - Genetic contribution

U2 - 10.1016/j.ygeno.2023.110616

DO - 10.1016/j.ygeno.2023.110616

M3 - Journal article

C2 - 36948276

SN - 0888-7543

VL - 115

JO - Genomics

JF - Genomics

IS - 3

M1 - 110616

ER -

Identifying genetic variants regulating MGMT gene expression: A study in monozygotic Danish twins

Abstract

Keywords

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