Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells

Christophe M. Capelle, Ni Zeng, Egle Danileviciute, Sabrina Freitas Rodrigues, Markus Ollert, Rudi Balling, Feng Q. He*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenoproteins in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both the E2F5 transcription regulatory pathway and the Ca2+/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising therapeutic target for various inflammation-associated diseases but also shows that our network-guided approach can significantly aid in predicting new functions of the genes of interest.

Original languageEnglish
Article number102289
JournaliScience
Volume24
Issue number4
Number of pages28
DOIs
Publication statusPublished - 23. Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s)

Keywords

  • Cell Biology
  • Immunology
  • Systems Biology

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