Hypoxia-regulated MicroRNAs in gastroesophageal cancer

M. Winther; J. Alsner; B.S. Sørensen; C. F. Wittrup; T Tramm; L Bæksgaard; K Hofland; E. Holtved; M Nordsmark

Hypoxia-regulated MicroRNAs in gastroesophageal cancer

M. Winther, J. Alsner, B.S. Sørensen, C. F. Wittrup, T Tramm, L Bæksgaard, K Hofland, E. Holtved, M Nordsmark

KI, OUH, Research unit of Oncology (Odense)

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

Original language	English
Journal	Anticancer Research
Volume	36
Issue number	2
Pages (from-to)	721-730
ISSN	0250-7005
Publication status	Published - 2016

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http://ar.iiarjournals.org/content/36/2/721.abstract?sid=fdaddca0-9804-402a-aecd-c950272ff83e

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Cite this

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title = "Hypoxia-regulated MicroRNAs in gastroesophageal cancer",

abstract = "Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p",

author = "M. Winther and J. Alsner and B.S. S{\o}rensen and Wittrup, {C. F.} and T Tramm and L B{\ae}ksgaard and K Hofland and E. Holtved and M Nordsmark",

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language = "English",

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TY - JOUR

T1 - Hypoxia-regulated MicroRNAs in gastroesophageal cancer

AU - Winther, M.

AU - Alsner, J.

AU - Sørensen, B.S.

AU - Wittrup, C. F.

AU - Tramm, T

AU - Bæksgaard, L

AU - Hofland, K

AU - Holtved, E.

AU - Nordsmark, M

N1 - Export Date: 22 March 2017 CODEN: ANTRD

PY - 2016

Y1 - 2016

N2 - Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

AB - Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

M3 - Journal article

SN - 0250-7005

VL - 36

SP - 721

EP - 730

JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -