Hypoglycemia in Pregnancies Following Gastric Bypass-a Systematic Review and Meta-analysis

Louise L Stentebjerg; Lene R Madsen; René K Støving; Claus B Juhl; Christina A Vinter; Lise Lotte T Andersen; Kristina Renault; Dorte M Jensen

doi:10.1007/s11695-022-06021-z

Hypoglycemia in Pregnancies Following Gastric Bypass-a Systematic Review and Meta-analysis

Louise L Stentebjerg^*, Lene R Madsen, René K Støving, Claus B Juhl, Christina A Vinter, Lise Lotte T Andersen, Kristina Renault, Dorte M Jensen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women's everyday-life using continuous glucose monitoring and mixed meal test.

Original language	English
Journal	Obesity Surgery
Volume	32
Issue number	6
Pages (from-to)	2047-2055
ISSN	0960-8923
DOIs	https://doi.org/10.1007/s11695-022-06021-z
Publication status	Published - Jun 2022

Keywords

Bariatric surgery
Continuous glucose monitoring
Hypoglycemia
Meta-analysis
Mixed meal test
Obesity
Oral glucose tolerance test
Pregnancy
Roux-en-Y gastric bypass
Systematic review
Gastric Bypass/adverse effects
Blood Glucose/metabolism
Humans
Obesity, Morbid/surgery
Blood Glucose Self-Monitoring
Hypoglycemia/complications
Female

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10.1007/s11695-022-06021-z

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1 Ph.D. thesis

Bariatric surgery And consequences for Mother and Baby In pregnancy: The BAMBI study
Stentebjerg, L. L., 20. Feb 2023, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 145 p.
Research output: Thesis › Ph.D. thesis

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Cite this

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title = "Hypoglycemia in Pregnancies Following Gastric Bypass-a Systematic Review and Meta-analysis",

abstract = "The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women's everyday-life using continuous glucose monitoring and mixed meal test.",

keywords = "Bariatric surgery, Continuous glucose monitoring, Hypoglycemia, Meta-analysis, Mixed meal test, Obesity, Oral glucose tolerance test, Pregnancy, Roux-en-Y gastric bypass, Systematic review, Gastric Bypass/adverse effects, Blood Glucose/metabolism, Humans, Obesity, Morbid/surgery, Blood Glucose Self-Monitoring, Hypoglycemia/complications, Female",

author = "Stentebjerg, {Louise L} and Madsen, {Lene R} and St{\o}ving, {Ren{\'e} K} and Juhl, {Claus B} and Vinter, {Christina A} and Andersen, {Lise Lotte T} and Kristina Renault and Jensen, {Dorte M}",

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AU - Stentebjerg, Louise L

AU - Madsen, Lene R

AU - Støving, René K

AU - Juhl, Claus B

AU - Vinter, Christina A

AU - Andersen, Lise Lotte T

AU - Renault, Kristina

AU - Jensen, Dorte M

PY - 2022/6

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N2 - The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women's everyday-life using continuous glucose monitoring and mixed meal test.

AB - The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women's everyday-life using continuous glucose monitoring and mixed meal test.

KW - Bariatric surgery

KW - Continuous glucose monitoring

KW - Hypoglycemia

KW - Meta-analysis

KW - Mixed meal test

KW - Obesity

KW - Oral glucose tolerance test

KW - Pregnancy

KW - Roux-en-Y gastric bypass

KW - Systematic review

KW - Gastric Bypass/adverse effects

KW - Blood Glucose/metabolism

KW - Humans

KW - Obesity, Morbid/surgery

KW - Blood Glucose Self-Monitoring

KW - Hypoglycemia/complications

KW - Female

U2 - 10.1007/s11695-022-06021-z

DO - 10.1007/s11695-022-06021-z

M3 - Journal article

C2 - 35332397

SN - 0960-8923

VL - 32

SP - 2047

EP - 2055

JO - Obesity Surgery

JF - Obesity Surgery

IS - 6

ER -

Hypoglycemia in Pregnancies Following Gastric Bypass-a Systematic Review and Meta-analysis

Abstract

Keywords

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Related research output

Bariatric surgery And consequences for Mother and Baby In pregnancy: The BAMBI study

Cite this