Hypoalbuminaemia as a marker of trans-capillary leakage in community-acquired bacteraemia patients

K. O. Gradel*, P. J. Vinholt, B. Magnussen, C. Pedersen, T. G. Jensen, H. J. Kolmos, A. T. Lassen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29.3 g/l on day 1 with little increase afterward. The mean CRP increased from day -5, peaked on day 1 and declined thereafter. The mean Hb level was fairly constant during days -30/30. Albumin was inversely (R range, - 0.18/-0.47, P < 10-4) correlated with the CRP level and positively (R = 0.17-0.46, P < 10-4) correlated with the HB level. In most models, CRP was the first variable that contributed to the albumin variations, 34-70% of the full model. The sudden decrease of albumin levels, without sudden fluctuations of CRP or Hb, indicated that hypoalbuminaemia was a marker of trans-capillary leakage.

Original languageEnglish
JournalEpidemiology and Infection
Volume146
Issue number5
Pages (from-to)648-655
ISSN0950-2688
DOIs
Publication statusPublished - Apr 2018

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Hypoalbuminemia
Albumins
Linear Models
Denmark

Keywords

  • Bloodstream infections
  • Septicaemia
  • Community-Acquired Infections/complications
  • Hypoalbuminemia/etiology
  • Humans
  • Middle Aged
  • C-Reactive Protein/analysis
  • Male
  • Bacteremia/complications
  • Young Adult
  • Adolescent
  • Aged, 80 and over
  • Denmark
  • Adult
  • Biomarkers/blood
  • Female
  • Aged
  • Population Surveillance

Cite this

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title = "Hypoalbuminaemia as a marker of trans-capillary leakage in community-acquired bacteraemia patients",
abstract = "Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29.3 g/l on day 1 with little increase afterward. The mean CRP increased from day -5, peaked on day 1 and declined thereafter. The mean Hb level was fairly constant during days -30/30. Albumin was inversely (R range, - 0.18/-0.47, P < 10-4) correlated with the CRP level and positively (R = 0.17-0.46, P < 10-4) correlated with the HB level. In most models, CRP was the first variable that contributed to the albumin variations, 34-70{\%} of the full model. The sudden decrease of albumin levels, without sudden fluctuations of CRP or Hb, indicated that hypoalbuminaemia was a marker of trans-capillary leakage.",
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author = "Gradel, {K. O.} and Vinholt, {P. J.} and B. Magnussen and C. Pedersen and Jensen, {T. G.} and Kolmos, {H. J.} and Lassen, {A. T.}",
year = "2018",
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language = "English",
volume = "146",
pages = "648--655",
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Hypoalbuminaemia as a marker of trans-capillary leakage in community-acquired bacteraemia patients. / Gradel, K. O.; Vinholt, P. J.; Magnussen, B.; Pedersen, C.; Jensen, T. G.; Kolmos, H. J.; Lassen, A. T.

In: Epidemiology and Infection, Vol. 146, No. 5, 04.2018, p. 648-655.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Hypoalbuminaemia as a marker of trans-capillary leakage in community-acquired bacteraemia patients

AU - Gradel, K. O.

AU - Vinholt, P. J.

AU - Magnussen, B.

AU - Pedersen, C.

AU - Jensen, T. G.

AU - Kolmos, H. J.

AU - Lassen, A. T.

PY - 2018/4

Y1 - 2018/4

N2 - Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29.3 g/l on day 1 with little increase afterward. The mean CRP increased from day -5, peaked on day 1 and declined thereafter. The mean Hb level was fairly constant during days -30/30. Albumin was inversely (R range, - 0.18/-0.47, P < 10-4) correlated with the CRP level and positively (R = 0.17-0.46, P < 10-4) correlated with the HB level. In most models, CRP was the first variable that contributed to the albumin variations, 34-70% of the full model. The sudden decrease of albumin levels, without sudden fluctuations of CRP or Hb, indicated that hypoalbuminaemia was a marker of trans-capillary leakage.

AB - Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29.3 g/l on day 1 with little increase afterward. The mean CRP increased from day -5, peaked on day 1 and declined thereafter. The mean Hb level was fairly constant during days -30/30. Albumin was inversely (R range, - 0.18/-0.47, P < 10-4) correlated with the CRP level and positively (R = 0.17-0.46, P < 10-4) correlated with the HB level. In most models, CRP was the first variable that contributed to the albumin variations, 34-70% of the full model. The sudden decrease of albumin levels, without sudden fluctuations of CRP or Hb, indicated that hypoalbuminaemia was a marker of trans-capillary leakage.

KW - Bloodstream infections

KW - Septicaemia

KW - Community-Acquired Infections/complications

KW - Hypoalbuminemia/etiology

KW - Humans

KW - Middle Aged

KW - C-Reactive Protein/analysis

KW - Male

KW - Bacteremia/complications

KW - Young Adult

KW - Adolescent

KW - Aged, 80 and over

KW - Denmark

KW - Adult

KW - Biomarkers/blood

KW - Female

KW - Aged

KW - Population Surveillance

U2 - 10.1017/S0950268818000274

DO - 10.1017/S0950268818000274

M3 - Journal article

C2 - 29457576

AN - SCOPUS:85042178466

VL - 146

SP - 648

EP - 655

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 5

ER -