Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study

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Abstract

PURPOSE: Graves' disease (GD) and toxic nodular goiter (TNG) are associated with various comorbidities. However, it is unclarified whether TNG and GD without orbitopathy are associated with glaucoma.

METHODS: This was a case-control study using record-linkage data from nationwide Danish health registers. 28,461 patients with GD and 17,283 with TNG were included. Each case was age and sex matched with four non-hyperthyroid controls and followed over a mean period of 8 years. Data on glaucoma was obtained by record linkage within the National Danish Patient Register and/or the Danish National Prescription Registry. Logistic and Cox regression models were used to assess the risk of glaucoma before and after the diagnosis of GD and TNG.

RESULTS: Compared to controls, there was a significantly increased frequency of glaucoma in patients with GD (4.6 vs. 4.2%, P = 0.006) and in patients with TNG (6.2 vs. 5.7%, P = 0.003). Prior to the diagnosis of hyperthyroidism, the odds ratio (OR) for glaucoma was non-significant in GD (1.09, 95% CI: 1.00-1.18) but slightly increased in TNG (1.13, 95% CI: 1.02-1.24). However, in TNG the OR attenuated completely when only including patients without co-morbidity in the analysis (1.03, 95% CI: 0.93-1.14). After adjustment for pre-existing co-morbidity, the hazard ratio (HR) for glaucoma following GD and TNG was not significantly increased (HR 1.08, 95% CI: 0.98-1.18 and HR 1.10, 95% CI: 0.99-1.21, respectively).

CONCLUSIONS: Neither prior to nor following the diagnosis of GD and TNG had any significant association with glaucoma.

Original languageEnglish
JournalEndocrine
Volume59
Issue number1
Pages (from-to)137–142
ISSN1355-008X
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Journal Article
  • Glaucoma
  • Toxic nodular goiter
  • Graves' disease
  • Register study
  • Hyperthyroidism/complications
  • Comorbidity
  • Humans
  • Middle Aged
  • Risk Factors
  • Male
  • Case-Control Studies
  • Denmark/epidemiology
  • Graves Ophthalmopathy/complications
  • Glaucoma/complications
  • Aged, 80 and over
  • Adult
  • Female
  • Registries
  • Aged

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