Human trophoblast interferons enhance major histocompatibility complex class I antigen expression on human term trophoblast cells in culture

H. Hager, G. Aboagye Mathiesen, P.M. Petersen, N. Norskov Lauritsen, C.B. Juhl, J.A. Villadsen, M. Zdravkovic, A. Gildberg, A.M. Dalsgaard, P. Ebbesen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The expression and regulation of major histocompatibility complex class I (MHC class I) antigens by virus-induced human trophoblast interferons (tro-IFNs) were examined in term trophoblast cultures. Flow cytometry studies using fluorescence monoclonal antibodies against MHC class I antigens revealed that isolated cytotrophoblasts can express MHC class I antigens. The expression of these antigens increased with stimulation of trophoblast cultures with tro-IFN-α and -β. One hundred IU tro-IFN-α and -β/ml induced no significant higher levels of MHC class I antigens as compared with the control, whereas 1000 IU tro-IFN-α and -β/ml did. The tro-IFN-enhanced expression of MHC class I antigens may be important as it increases the efficiency of local and viral antigen presentation, cytotoxicity by T cell response and local inflammatory processes, thereby preventing virus spread from mother to fetus.
Original languageEnglish
JournalPlacenta
Volume15
Issue number7
Pages (from-to)709-714
ISSN0143-4004
DOIs
Publication statusPublished - 1994
Externally publishedYes

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