Human intestinal P-glycoprotein activity estimated by the model substrate digoxin

U L Larsen, L Hyldahl Olesen, Charlotte Guldborg Nyvold, J Eriksen, P Jakobsen, M Østergaard, Herman Autrup, Vibeke Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

P-glycoprotein (Pgp) plays a part in the intestinal uptake of xenobiotics and has been associated with susceptibility to ulcerative colitis. The aim of this study was to examine Pgp activity in relation to age, gender, medical treatment (rifampicin or ketoconazole) and the multidrug resistance (MDR1) gene single nucleotide polymorphisms (SNPs) G2677T and C3435T using the model drug digoxin.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume67
Issue number2
Pages (from-to)123-34
ISSN0036-5513
DOIs
Publication statusPublished - 2007

Keywords

  • Adult
  • Aged
  • Area Under Curve
  • Blotting, Western
  • Cardiotonic Agents
  • Digoxin
  • Drug Interactions
  • Duodenum
  • Female
  • Gene Expression
  • Homozygote
  • Humans
  • Ketoconazole
  • Male
  • Middle Aged
  • P-Glycoprotein
  • Polymorphism, Restriction Fragment Length
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rifampin

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