Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11

Mette Falkenberg Krantz; Carsten Hjorthøj; Julie Marie Brandt; Åsa Kremer Prøsch; Sinnika Birkehøj Rohd; Martin Wilms; Lotte Veddum; Nanna Lawaetz Steffensen; Christina Bruun Knudsen; Anna Krogh Andreasen; Henriette Stadsgaard; Nicoline Hemager; Birgitte Klee Burton; Maja Gregersen; Anne Søndergaard; Aja Greve; Ditte Lou Gantriis; Marianne Melau; Jessica Ohland; Preben Bo Mortensen; Vibeke Bliksted; Ole Mors; Anne A.E. Thorup; Merete Nordentoft

doi:10.1017/S0033291721004487

Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11

Mette Falkenberg Krantz^*
, Carsten Hjorthøj
, Julie Marie Brandt
, Åsa Kremer Prøsch
, Sinnika Birkehøj Rohd
, Martin Wilms
, Lotte Veddum
, Nanna Lawaetz Steffensen
, Christina Bruun Knudsen
, Anna Krogh Andreasen
, Henriette Stadsgaard
, Nicoline Hemager
, Birgitte Klee Burton
, Maja Gregersen
, Anne Søndergaard
, Aja Greve
, Ditte Lou Gantriis
, Marianne Melau
, Jessica Ohland
, Preben Bo Mortensen

Vibeke Bliksted, Ole Mors, Anne A.E. Thorup, Merete Nordentoft

^*Corresponding author for this work

Aarhus University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background The home environment has a major impact on child development. Parental severe mental illness can pose a challenge to the home environment of a child. We aimed to examine the home environment of children of parents with schizophrenia or bipolar disorder and controls longitudinally through at-home assessments. Methods Assessments were conducted within The Danish High Risk and Resilience Study, a nationwide multi-center cohort study of children of parents with schizophrenia or bipolar disorder and population-based controls. The level of at-home stimulation and support was measured at age 7 (N = 508 children) and age 11 (N = 430 children) with the semi-structured HOME Inventory. Results from the 11-year follow-up study were analyzed and compared with 7-year baseline results to examine change across groups. Results At age 11, children of parents with schizophrenia and bipolar disorder had lower levels of stimulation and support than controls (mean (s.d.) = 46.16 (5.56), 46.87 (5.34) and 49.25 (4.37) respectively, p < 0.001). A higher proportion of children with parental schizophrenia or bipolar disorder lived in inadequate home environments at age 11, compared with controls (N (%) = 24 (15.0), 12 (12.2) and 6 (3.5) respectively, p < 0.003). The changes in home environment scores did not differ across groups from age 7 to age 11. Conclusions Assessed longitudinally from the children's age of 7 to 11, children of parents with schizophrenia or bipolar disorder had lower levels of stimulation and support in their homes than controls. Integrated support which can target practical, economic, social and health issues to improve the home environment is indicated.

Original language	English
Journal	Psychological Medicine
Volume	53
Issue number	6
Pages (from-to)	2563-2573
Number of pages	11
ISSN	0033-2917
DOIs	https://doi.org/10.1017/S0033291721004487
Publication status	Published - Apr 2023
Externally published	Yes

Funding

We thank the children and parents who participated in the study for their great contribution. We also thank Marianne Giørtz Pedersen and Carsten Bøcker Pedersen for their great contribution on the extraction of data from registers, and Benthe Emke Vink and Gøcke Mine Akkas for their great contribution with the data handling. This study was supported by The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), the Mental Health Services at the Capital Region of Denmark, Copenhagen University, Aarhus University, The Beatrice Surovell Haskell Fund and the Tryg Foundation. The funding sources had no influence on the study design or the reporting of data. All authors had full access to all the data in the study and accept responsibility for publication. The Danish High Risk and Resilience Study has received economic support from The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH, grant number R102-A9118 and R155-2014-1724), the Mental Health Services of the Capital Region of Denmark, University of Aarhus, University of Copenhagen, The Tryg Foundation, and The Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen. The funding sources have not had any influence on the study design or the reporting of data.

Keywords

Bipolar Disorder
Child
Cohort Studies
Denmark/epidemiology
Follow-Up Studies
Home Environment
Humans
Parents
Schizophrenia/epidemiology

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Krantz, M. F., Hjorthøj, C., Brandt, J. M., Prøsch, Å. K., Rohd, S. B., Wilms, M., Veddum, L., Steffensen, N. L., Knudsen, C. B., Andreasen, A. K., Stadsgaard, H., Hemager, N., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A., Gantriis, D. L., Melau, M., Ohland, J., ... Nordentoft, M. (2023). Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11. Psychological Medicine, 53(6), 2563-2573. https://doi.org/10.1017/S0033291721004487

@article{d7e3d38d3a414dcaad9ac4e871c3faa4,

title = "Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11",

abstract = "Background The home environment has a major impact on child development. Parental severe mental illness can pose a challenge to the home environment of a child. We aimed to examine the home environment of children of parents with schizophrenia or bipolar disorder and controls longitudinally through at-home assessments. Methods Assessments were conducted within The Danish High Risk and Resilience Study, a nationwide multi-center cohort study of children of parents with schizophrenia or bipolar disorder and population-based controls. The level of at-home stimulation and support was measured at age 7 (N = 508 children) and age 11 (N = 430 children) with the semi-structured HOME Inventory. Results from the 11-year follow-up study were analyzed and compared with 7-year baseline results to examine change across groups. Results At age 11, children of parents with schizophrenia and bipolar disorder had lower levels of stimulation and support than controls (mean (s.d.) = 46.16 (5.56), 46.87 (5.34) and 49.25 (4.37) respectively, p < 0.001). A higher proportion of children with parental schizophrenia or bipolar disorder lived in inadequate home environments at age 11, compared with controls (N (\%) = 24 (15.0), 12 (12.2) and 6 (3.5) respectively, p < 0.003). The changes in home environment scores did not differ across groups from age 7 to age 11. Conclusions Assessed longitudinally from the children's age of 7 to 11, children of parents with schizophrenia or bipolar disorder had lower levels of stimulation and support in their homes than controls. Integrated support which can target practical, economic, social and health issues to improve the home environment is indicated.",

keywords = "Bipolar Disorder, Child, Cohort Studies, Denmark/epidemiology, Follow-Up Studies, Home Environment, Humans, Parents, Schizophrenia/epidemiology",

author = "Krantz, \{Mette Falkenberg\} and Carsten Hjorth{\o}j and Brandt, \{Julie Marie\} and Pr{\o}sch, \{{\AA}sa Kremer\} and Rohd, \{Sinnika Birkeh{\o}j\} and Martin Wilms and Lotte Veddum and Steffensen, \{Nanna Lawaetz\} and Knudsen, \{Christina Bruun\} and Andreasen, \{Anna Krogh\} and Henriette Stadsgaard and Nicoline Hemager and Burton, \{Birgitte Klee\} and Maja Gregersen and Anne S{\o}ndergaard and Aja Greve and Gantriis, \{Ditte Lou\} and Marianne Melau and Jessica Ohland and Mortensen, \{Preben Bo\} and Vibeke Bliksted and Ole Mors and Thorup, \{Anne A.E.\} and Merete Nordentoft",

note = "Funding Information: We thank the children and parents who participated in the study for their great contribution. We also thank Marianne Gi{\o}rtz Pedersen and Carsten B{\o}cker Pedersen for their great contribution on the extraction of data from registers, and Benthe Emke Vink and G{\o}cke Mine Akkas for their great contribution with the data handling. This study was supported by The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), the Mental Health Services at the Capital Region of Denmark, Copenhagen University, Aarhus University, The Beatrice Surovell Haskell Fund and the Tryg Foundation. The funding sources had no influence on the study design or the reporting of data. All authors had full access to all the data in the study and accept responsibility for publication. Funding Information: The Danish High Risk and Resilience Study has received economic support from The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH, grant number R102-A9118 and R155-2014-1724), the Mental Health Services of the Capital Region of Denmark, University of Aarhus, University of Copenhagen, The Tryg Foundation, and The Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen. The funding sources have not had any influence on the study design or the reporting of data. Publisher Copyright: Copyright {\textcopyright} The Author(s), 2021. Published by Cambridge University Press.",

year = "2023",

month = apr,

doi = "10.1017/S0033291721004487",

language = "English",

volume = "53",

pages = "2563--2573",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "6",

}

Krantz, MF, Hjorthøj, C, Brandt, JM, Prøsch, ÅK, Rohd, SB, Wilms, M, Veddum, L, Steffensen, NL, Knudsen, CB, Andreasen, AK, Stadsgaard, H, Hemager, N, Burton, BK, Gregersen, M, Søndergaard, A, Greve, A, Gantriis, DL, Melau, M, Ohland, J, Mortensen, PB, Bliksted, V, Mors, O, Thorup, AAE & Nordentoft, M 2023, 'Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11', Psychological Medicine, vol. 53, no. 6, pp. 2563-2573. https://doi.org/10.1017/S0033291721004487

Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11. / Krantz, Mette Falkenberg; Hjorthøj, Carsten; Brandt, Julie Marie et al.
In: Psychological Medicine, Vol. 53, No. 6, 04.2023, p. 2563-2573.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study

T2 - The Danish High Risk and Resilience Study - VIA 11

AU - Krantz, Mette Falkenberg

AU - Hjorthøj, Carsten

AU - Brandt, Julie Marie

AU - Prøsch, Åsa Kremer

AU - Rohd, Sinnika Birkehøj

AU - Wilms, Martin

AU - Veddum, Lotte

AU - Steffensen, Nanna Lawaetz

AU - Knudsen, Christina Bruun

AU - Andreasen, Anna Krogh

AU - Stadsgaard, Henriette

AU - Hemager, Nicoline

AU - Burton, Birgitte Klee

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja

AU - Gantriis, Ditte Lou

AU - Melau, Marianne

AU - Ohland, Jessica

AU - Mortensen, Preben Bo

AU - Bliksted, Vibeke

AU - Mors, Ole

AU - Thorup, Anne A.E.

AU - Nordentoft, Merete

N1 - Funding Information: We thank the children and parents who participated in the study for their great contribution. We also thank Marianne Giørtz Pedersen and Carsten Bøcker Pedersen for their great contribution on the extraction of data from registers, and Benthe Emke Vink and Gøcke Mine Akkas for their great contribution with the data handling. This study was supported by The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), the Mental Health Services at the Capital Region of Denmark, Copenhagen University, Aarhus University, The Beatrice Surovell Haskell Fund and the Tryg Foundation. The funding sources had no influence on the study design or the reporting of data. All authors had full access to all the data in the study and accept responsibility for publication. Funding Information: The Danish High Risk and Resilience Study has received economic support from The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH, grant number R102-A9118 and R155-2014-1724), the Mental Health Services of the Capital Region of Denmark, University of Aarhus, University of Copenhagen, The Tryg Foundation, and The Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen. The funding sources have not had any influence on the study design or the reporting of data. Publisher Copyright: Copyright © The Author(s), 2021. Published by Cambridge University Press.

PY - 2023/4

Y1 - 2023/4

N2 - Background The home environment has a major impact on child development. Parental severe mental illness can pose a challenge to the home environment of a child. We aimed to examine the home environment of children of parents with schizophrenia or bipolar disorder and controls longitudinally through at-home assessments. Methods Assessments were conducted within The Danish High Risk and Resilience Study, a nationwide multi-center cohort study of children of parents with schizophrenia or bipolar disorder and population-based controls. The level of at-home stimulation and support was measured at age 7 (N = 508 children) and age 11 (N = 430 children) with the semi-structured HOME Inventory. Results from the 11-year follow-up study were analyzed and compared with 7-year baseline results to examine change across groups. Results At age 11, children of parents with schizophrenia and bipolar disorder had lower levels of stimulation and support than controls (mean (s.d.) = 46.16 (5.56), 46.87 (5.34) and 49.25 (4.37) respectively, p < 0.001). A higher proportion of children with parental schizophrenia or bipolar disorder lived in inadequate home environments at age 11, compared with controls (N (%) = 24 (15.0), 12 (12.2) and 6 (3.5) respectively, p < 0.003). The changes in home environment scores did not differ across groups from age 7 to age 11. Conclusions Assessed longitudinally from the children's age of 7 to 11, children of parents with schizophrenia or bipolar disorder had lower levels of stimulation and support in their homes than controls. Integrated support which can target practical, economic, social and health issues to improve the home environment is indicated.

AB - Background The home environment has a major impact on child development. Parental severe mental illness can pose a challenge to the home environment of a child. We aimed to examine the home environment of children of parents with schizophrenia or bipolar disorder and controls longitudinally through at-home assessments. Methods Assessments were conducted within The Danish High Risk and Resilience Study, a nationwide multi-center cohort study of children of parents with schizophrenia or bipolar disorder and population-based controls. The level of at-home stimulation and support was measured at age 7 (N = 508 children) and age 11 (N = 430 children) with the semi-structured HOME Inventory. Results from the 11-year follow-up study were analyzed and compared with 7-year baseline results to examine change across groups. Results At age 11, children of parents with schizophrenia and bipolar disorder had lower levels of stimulation and support than controls (mean (s.d.) = 46.16 (5.56), 46.87 (5.34) and 49.25 (4.37) respectively, p < 0.001). A higher proportion of children with parental schizophrenia or bipolar disorder lived in inadequate home environments at age 11, compared with controls (N (%) = 24 (15.0), 12 (12.2) and 6 (3.5) respectively, p < 0.003). The changes in home environment scores did not differ across groups from age 7 to age 11. Conclusions Assessed longitudinally from the children's age of 7 to 11, children of parents with schizophrenia or bipolar disorder had lower levels of stimulation and support in their homes than controls. Integrated support which can target practical, economic, social and health issues to improve the home environment is indicated.

KW - Bipolar Disorder

KW - Child

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Follow-Up Studies

KW - Home Environment

KW - Humans

KW - Parents

KW - Schizophrenia/epidemiology

U2 - 10.1017/S0033291721004487

DO - 10.1017/S0033291721004487

M3 - Journal article

C2 - 37310315

AN - SCOPUS:85120785502

SN - 0033-2917

VL - 53

SP - 2563

EP - 2573

JO - Psychological Medicine

JF - Psychological Medicine

IS - 6

ER -

Home environment of 11-year-old children born to parents with schizophrenia or bipolar disorder - A controlled, 4-year follow-up study: The Danish High Risk and Resilience Study - VIA 11

Abstract

Funding

Keywords

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SDU Link

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