HLA-B*27 is significantly enriched in Nordic patients with psoriatic arthritis mutilans

Pernilla Nikamo, Bjorn Gudbjornsson, Leena Laasonen, Leif Ejstrup, Lars Iversen, Ulla Lindqvist, Leonid Padyukov, Mona Ståhle

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVES: The genetic contribution to psoriatic disease is substantial with a dominating influence of the HLA region. The profile of HLA class I genotypes likely contributes to shaping clinical phenotypes. Herein we aimed to explore such genotypes in cohorts of closely characterised subsets of psoriatic disease with special focus on psoriatic arthritis mutilans (PAM), a severe and rare form of psoriatic arthritis (PsA).

METHODS: Cohorts of patients with the diagnosis of psoriasis vulgaris with or without arthritis (n=1217), psoriasis without arthritis (n=534), psoriatic arthritis without mutilating disease (n=337) and psoriatic arthritis mutilans (n=63) were collected and genotyped for HLA class I and II genes, with standardised methodologies. Cases were compared with a healthy control population (n=2468). Case-only and case-control association tests were performed to address the hypothesis of genetic contribution to clinical phenotypes.

RESULTS: The presence of HLA-B*27 was strikingly increased in PAM (45%) compared with PsA without mutilating disease (13%) and with healthy controls (13%). However, within the PAM population, HLA-B*27 did not correlate with clinical markers such as number of mutilating joints, radiographic scoring, disease duration and age of disease onset.

CONCLUSIONS: HLA-B*27 emerges as an important genotype marker for PAM.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume39
Issue number4
Pages (from-to)775-780
ISSN0392-856X
DOIs
Publication statusPublished - 2021

Keywords

  • Arthritis, Psoriatic/diagnosis
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-B Antigens/genetics
  • Humans
  • Phenotype
  • Psoriasis
  • HLA-genotyping
  • Mutilans
  • Arthritis
  • HLA-B*27

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