Hippocampal neurodegeneration and rhythms mirror each other during acute spinal cord injury in male rats

Hamid Soltani Zangbar, Parviz Shahabi*, Manouchehr Seyedi Vafaee, Tahereh Ghadiri, Abbas Ebrahimi Kalan, Solmaz Fallahi, Meysam Ghorbani, Mohsen Jafarzadehgharehziaaddin

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Spinal Cord Injury (SCI), triggers neurodegenerative changes in the spinal cord, and simultaneously alters oscillatory manifestations of motor cortex. However, these disturbances may not be limited to motor areas and other parts such as hippocampus, which is vital in the neurogenesis and cognitive function, may be affected in the neurogenic and oscillatory manners. Addressing this remarkable complication of SCI, we evaluated the hippocampal neurogenesis and rhythms through acute phase of SCI. In the present study, we used 40 male rats (Sham.W1 = 10, SCI.W1 = 10, Sham.W2 = 10, SCI.W2 = 10), and findings revealed that contusive SCI declines hippocampal rhythms (Delta, Theta, Beta, Gamma) power and max-frequency. Also, there was a significant decrease in the DCX + and BrdU + cells of the dentate gyrus; correlated significantly with rhythms power decline. Considering the TUNEL assay analysis, there were significantly greater apoptotic cells, in the CA1, CA3, and DG regions of injured animals. Furthermore, according to the western blotting analysis, the expression of receptors (NMDA, GABAA, Muscarinic1), which are essential in the neurogenesis and generation of rhythms significantly attenuated following SCI. Our study demonstrated that acute SCI, alters the power and max-frequency of hippocampal rhythms parallel with changes in the hippocampal neurogenesis, apoptosis, and receptors expression.

Original languageEnglish
JournalBrain Research Bulletin
Volume172
Pages (from-to)31-42
ISSN0361-9230
DOIs
Publication statusPublished - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

  • Hippocampal rhythms
  • Hippocampus
  • Neurogenesis
  • Spinal cord injury

Fingerprint

Dive into the research topics of 'Hippocampal neurodegeneration and rhythms mirror each other during acute spinal cord injury in male rats'. Together they form a unique fingerprint.

Cite this