High sensitivity of quick view capsule endoscopy for detection of small bowel Crohn's disease

Morten Lee Halling, Torben Nathan, Jens Kjeldsen, Michael Dam Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background and Aim: Capsule endoscopy (CE) has a high sensitivity for diagnosing small bowel Crohn's disease, but video analysis is time-consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv-CE compared with standard view and the diagnostic accuracy of qv-CE in suspected Crohn's disease. Methods: This study consisted of two parts: (i) 12 small bowel segments with Crohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with CE and qv-CE, and (ii) a blinded study of the diagnostic accuracy of qv-CE including 40 patients with suspected Crohn's disease. Ileocolonoscopy and CE served as gold standard. Results: Part 1: CE visualized 171 ulcerations compared with 102 detected with qv-CE (miss rate 40%, P=0.02). Part 2: qv-CE identified 15 of 16 patients with small bowel Crohn's disease corresponding to a 94% sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98%). Qv-CE was false negative in one patient because of a leap of 3min and 20s in the terminal ileum. Reading times varied from 5 to 18min (median 10). Conclusion: Despite a significant number of missed lesions, qv-CE is a safe and time-reducing method for diagnosing small bowel Crohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology
Volume29
Issue number5
Pages (from-to)992-996
ISSN0815-9319
DOIs
Publication statusPublished - May 2014

Fingerprint

Capsule Endoscopy
Crohn Disease
Ileum
Reading

Keywords

  • Capsule endoscopy
  • Crohn's disease
  • Quick view
  • Sensitivity and specificity
  • Small intestine
  • Severity of Illness Index
  • Humans
  • Middle Aged
  • Intestine, Small/pathology
  • Male
  • Young Adult
  • Crohn Disease/diagnosis
  • Sensitivity and Specificity
  • Adolescent
  • Adult
  • Female
  • Aged
  • Capsule Endoscopy/methods

Cite this

@article{5b697975fdbf44c989018c21522f11de,
title = "High sensitivity of quick view capsule endoscopy for detection of small bowel Crohn's disease",
abstract = "Background and Aim: Capsule endoscopy (CE) has a high sensitivity for diagnosing small bowel Crohn's disease, but video analysis is time-consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv-CE compared with standard view and the diagnostic accuracy of qv-CE in suspected Crohn's disease. Methods: This study consisted of two parts: (i) 12 small bowel segments with Crohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with CE and qv-CE, and (ii) a blinded study of the diagnostic accuracy of qv-CE including 40 patients with suspected Crohn's disease. Ileocolonoscopy and CE served as gold standard. Results: Part 1: CE visualized 171 ulcerations compared with 102 detected with qv-CE (miss rate 40{\%}, P=0.02). Part 2: qv-CE identified 15 of 16 patients with small bowel Crohn's disease corresponding to a 94{\%} sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98{\%}). Qv-CE was false negative in one patient because of a leap of 3min and 20s in the terminal ileum. Reading times varied from 5 to 18min (median 10). Conclusion: Despite a significant number of missed lesions, qv-CE is a safe and time-reducing method for diagnosing small bowel Crohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.",
keywords = "Capsule endoscopy, Crohn's disease, Quick view, Sensitivity and specificity, Small intestine, Severity of Illness Index, Humans, Middle Aged, Intestine, Small/pathology, Male, Young Adult, Crohn Disease/diagnosis, Sensitivity and Specificity, Adolescent, Adult, Female, Aged, Capsule Endoscopy/methods",
author = "Halling, {Morten Lee} and Torben Nathan and Jens Kjeldsen and Jensen, {Michael Dam}",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
month = "5",
doi = "10.1111/jgh.12488",
language = "English",
volume = "29",
pages = "992--996",
journal = "Journal of Gastroenterology and Hepatology",
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High sensitivity of quick view capsule endoscopy for detection of small bowel Crohn's disease. / Halling, Morten Lee; Nathan, Torben; Kjeldsen, Jens; Jensen, Michael Dam.

In: Journal of Gastroenterology and Hepatology, Vol. 29, No. 5, 05.2014, p. 992-996.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - High sensitivity of quick view capsule endoscopy for detection of small bowel Crohn's disease

AU - Halling, Morten Lee

AU - Nathan, Torben

AU - Kjeldsen, Jens

AU - Jensen, Michael Dam

N1 - This article is protected by copyright. All rights reserved.

PY - 2014/5

Y1 - 2014/5

N2 - Background and Aim: Capsule endoscopy (CE) has a high sensitivity for diagnosing small bowel Crohn's disease, but video analysis is time-consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv-CE compared with standard view and the diagnostic accuracy of qv-CE in suspected Crohn's disease. Methods: This study consisted of two parts: (i) 12 small bowel segments with Crohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with CE and qv-CE, and (ii) a blinded study of the diagnostic accuracy of qv-CE including 40 patients with suspected Crohn's disease. Ileocolonoscopy and CE served as gold standard. Results: Part 1: CE visualized 171 ulcerations compared with 102 detected with qv-CE (miss rate 40%, P=0.02). Part 2: qv-CE identified 15 of 16 patients with small bowel Crohn's disease corresponding to a 94% sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98%). Qv-CE was false negative in one patient because of a leap of 3min and 20s in the terminal ileum. Reading times varied from 5 to 18min (median 10). Conclusion: Despite a significant number of missed lesions, qv-CE is a safe and time-reducing method for diagnosing small bowel Crohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.

AB - Background and Aim: Capsule endoscopy (CE) has a high sensitivity for diagnosing small bowel Crohn's disease, but video analysis is time-consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv-CE compared with standard view and the diagnostic accuracy of qv-CE in suspected Crohn's disease. Methods: This study consisted of two parts: (i) 12 small bowel segments with Crohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with CE and qv-CE, and (ii) a blinded study of the diagnostic accuracy of qv-CE including 40 patients with suspected Crohn's disease. Ileocolonoscopy and CE served as gold standard. Results: Part 1: CE visualized 171 ulcerations compared with 102 detected with qv-CE (miss rate 40%, P=0.02). Part 2: qv-CE identified 15 of 16 patients with small bowel Crohn's disease corresponding to a 94% sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98%). Qv-CE was false negative in one patient because of a leap of 3min and 20s in the terminal ileum. Reading times varied from 5 to 18min (median 10). Conclusion: Despite a significant number of missed lesions, qv-CE is a safe and time-reducing method for diagnosing small bowel Crohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.

KW - Capsule endoscopy

KW - Crohn's disease

KW - Quick view

KW - Sensitivity and specificity

KW - Small intestine

KW - Severity of Illness Index

KW - Humans

KW - Middle Aged

KW - Intestine, Small/pathology

KW - Male

KW - Young Adult

KW - Crohn Disease/diagnosis

KW - Sensitivity and Specificity

KW - Adolescent

KW - Adult

KW - Female

KW - Aged

KW - Capsule Endoscopy/methods

U2 - 10.1111/jgh.12488

DO - 10.1111/jgh.12488

M3 - Journal article

C2 - 24325204

VL - 29

SP - 992

EP - 996

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

SN - 0815-9319

IS - 5

ER -