Research output per year
Research output per year
Maria Houborg Petersen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund*
Research output: Contribution to journal › Journal article › Research › peer-review
AIMS: Non-weight-bearing high-intensity interval training (HIIT) involving several muscle groups may efficiently improve metabolic health without compromising adherence in obesity and type 2 diabetes. In a non-randomized intervention study, we examined the effect of a novel HIIT-protocol, recruiting both lower and upper body muscles, on insulin sensitivity, measures of metabolic health and adherence in obesity and type 2 diabetes.
METHODS: In 15 obese men with type 2 diabetes and age-matched obese (<i>n</i>=15) and lean (<i>n</i>=18) glucose-tolerant men, the effects of 8-weeks supervised HIIT combining rowing and cycling on ergometers (3 sessions/week) were examined by DXA-scan, incremental exercise test and hyperinsulinemic-euglycemic clamp combined with indirect calorimetry.
RESULTS: At baseline, insulin-stimulated glucose disposal rate (GDR) was ~40% reduced in the diabetic vs the non-diabetic groups (all <i>p</i><0.01). In response to HIIT, insulin-stimulated GDR increased ~30-40% in all groups (all <i>p</i><0.01) entirely explained by increased glucose storage. These changes were accompanied by ~8-15% increases in VO<sub>2</sub>max, (all <i>p</i><0.01), decreased total fat mass and increased lean body mass in all groups (all <i>p</i><0.05). There were no correlations between these training adaptations and no group-differences in these responses. HbA1c showed a clinically relevant decrease in men with type 2 diabetes (4±2 mmol/mol; <i>p</i><0.05). Importantly, adherence was high (>95%) in all groups and no injuries were reported.
CONCLUSIONS: A novel HIIT-protocol recruiting lower and upper body muscles efficiently improves insulin sensitivity, VO<sub>2</sub>max and body composition with intact responses in obesity and type 2 diabetes. The high adherence and lack of injuries show that non-weight-bearing HIIT involving several muscle groups is a promising mode of exercise training in obesity and type 2 diabetes.
Original language | English |
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Article number | 1032235 |
Journal | Frontiers in Endocrinology |
Volume | 13 |
ISSN | 1664-2392 |
DOIs | |
Publication status | Published - 1. Nov 2022 |
Research output: Thesis › Ph.D. thesis
Research output: Thesis › Ph.D. thesis