Abstract

PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.

METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.

RESULTS: Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm(3); 0-50.5 mm(3) vs 0; 0-34.3 mm(3), p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume ( τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume ( p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.

CONCLUSION: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

Original languageEnglish
JournalDiabetes and Vascular Disease Research
Volume14
Issue number6
Pages (from-to)468-476
ISSN1479-1641
DOIs
Publication statusPublished - 2017

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Type 2 Diabetes Mellitus
Coronary Artery Disease
Hyperglycemia
Multivariate Analysis
Smoking
Odds Ratio

Keywords

  • Journal Article

Cite this

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title = "High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes",
abstract = "PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.RESULTS: Coronary artery calcification was more often seen in patients with type 2 diabetes (66{\%}) versus controls (48{\%}), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm(3); 0-50.5 mm(3) vs 0; 0-34.3 mm(3), p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume ( τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31{\%} vs 0{\%}, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume ( p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.CONCLUSION: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.",
keywords = "Journal Article",
author = "Monija Mrgan and Funck, {Kristian L} and Sara Gaur and {\O}vrehus, {Kristian A} and Damini Dey and Kusk, {Martin W} and N{\o}rgaard, {Bjarne L} and Gram, {J{\o}rgen B} and Olsen, {Michael H} and Jeppe Gram and Sand, {Niels Peter R}",
year = "2017",
doi = "10.1177/1479164117728014",
language = "English",
volume = "14",
pages = "468--476",
journal = "Diabetes and Vascular Disease Research",
issn = "1479-1641",
publisher = "SAGE Publications",
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}

High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. / Mrgan, Monija; Funck, Kristian L; Gaur, Sara; Øvrehus, Kristian A; Dey, Damini; Kusk, Martin W; Nørgaard, Bjarne L; Gram, Jørgen B; Olsen, Michael H; Gram, Jeppe; Sand, Niels Peter R.

In: Diabetes and Vascular Disease Research, Vol. 14, No. 6, 2017, p. 468-476.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes

AU - Mrgan, Monija

AU - Funck, Kristian L

AU - Gaur, Sara

AU - Øvrehus, Kristian A

AU - Dey, Damini

AU - Kusk, Martin W

AU - Nørgaard, Bjarne L

AU - Gram, Jørgen B

AU - Olsen, Michael H

AU - Gram, Jeppe

AU - Sand, Niels Peter R

PY - 2017

Y1 - 2017

N2 - PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.RESULTS: Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm(3); 0-50.5 mm(3) vs 0; 0-34.3 mm(3), p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume ( τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume ( p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.CONCLUSION: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

AB - PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.RESULTS: Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm(3); 0-50.5 mm(3) vs 0; 0-34.3 mm(3), p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume ( τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume ( p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.CONCLUSION: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

KW - Journal Article

U2 - 10.1177/1479164117728014

DO - 10.1177/1479164117728014

M3 - Journal article

C2 - 28866908

VL - 14

SP - 468

EP - 476

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

SN - 1479-1641

IS - 6

ER -